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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제3호
- 발행연도
- 2021.8
- 수록면
- 303 - 311 (9page)
- DOI
- https://doi.org/10.21053/ceo.2020.01907
이용수
초록· 키워드
오류제보하기
Objectives. The emergence of electronic cigarettes (e-cigarettes) has created new perceptions of the tobacco market. Unlike traditional tobacco, the greatest advantage of e-cigarettes is that they have less smell and are convenient and inexpensive. Most e-cigarette smokers believe that e-cigarette smoking is less harmful than traditional smoking. Information on the effects of e-cigarettes on human health is limited, and the issue remains controversial.
Methods. We studied the effects of e-cigarette vapor on mucin (MUC5AC and MUC5B) and the change of MUC5AC and MUC5B from e-cigarette liquid with or without nicotine in respiratory epithelial cells. The effects of e-cigarette vapor with or without nicotine on mucin, along with the involved signaling pathways, were investigated using reverse transcriptase-polymerase chain reaction (PCR), real-time PCR, enzyme immunoassays, and immunoblot analysis with several specific inhibitors and small interfering RNA.
Results. E-cigarette vapor with or without nicotine stimulated MUC5AC, but not MUC5B, expression in respiratory epithelial cells. In addition, we showed that e-cigarette vapor with and without nicotine induced MUC5AC expression via activation of the mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase [ERK] 1/2 and p38) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways in human airway epithelial cells.
Conclusion. E-cigarette vapor with and with nicotine significantly increased MUC5AC expression in human airway epithelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Thornton SL / 2014 / Fatal intravenous injection of electronic nicotine delivery system refilling solution / J Med Toxicol 10(2):202~204
Chen EY / 2014 / Nicotine alters mucin rheological properties / Am J Physiol Lung Cell Mol Physiol 307(2):L149~L157
Kozlowski LT / 2005 / An extremely compensatible cigarette by design: documentary evidence on industry awareness and reactions to the Barclay filter design cheating the tar testing system / Tob Control 14(1):64~70
Farsalinos KE / 2013 / Evaluation of electronic cigarette use (vaping) topography and estimation of liquid consumption: implications for research protocol standards definition and for public health authorities’ regulation / Int J Environ Res Public Health 10(6):2500~2514
Farsalinos KE / 2013 / Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells / Int J Environ Res Public Health 10(10):5146~5162
Chen EY / 2014 / Nicotine alters mucin rheological properties / Am J Physiol Lung Cell Mol Physiol 307(2):L149~L157
Kozlowski LT / 2005 / An extremely compensatible cigarette by design: documentary evidence on industry awareness and reactions to the Barclay filter design cheating the tar testing system / Tob Control 14(1):64~70
Farsalinos KE / 2013 / Evaluation of electronic cigarette use (vaping) topography and estimation of liquid consumption: implications for research protocol standards definition and for public health authorities’ regulation / Int J Environ Res Public Health 10(6):2500~2514
Farsalinos KE / 2013 / Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells / Int J Environ Res Public Health 10(10):5146~5162
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