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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 17 - 23 (7page)
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초록· 키워드
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Background and Objectives: Insulin is a peptide hormone that regulates the metabolism of carbohydrates and fats by promoting the absorption of glucose from the blood to skeletal muscles. Insulin has been reported to be closely related to cardiovascular, respiratory, and endocrine disease. However, the effect of insulin on production of major mucins in human airway epithelial cells has not been reported. Therefore, this study investigated the relationship between high levels of insulin and mucin in human airway epithelial cells. Materials and Methods: This study analyzed the effect of high level of insulin on MUC4, MUC5AC, and MUC5B expression using reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay in human airway epithelial cells. Results: In human NCI-H292 airway epithelial cells, high level of insulin significant increased MUC4, MUC5AC, and MUC5B mRNA expression and glycoprotein production. In the primary cultures of normal nasal epithelial cells, high level of insulin also increased MUC4, MUC5AC, and MUC5B expression. Conclusion: These results suggest that insulin plays a role in control of mucus hypersecretion in human airway epithelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Fahy JV / 2010 / Airway mucus function and dysfunction / N Engl J Med 363:2233~2247
Rose MC / 2001 / Airway mucus obstruction: Mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia / Am J Respir Cell Mol Biol 25:533~537
Rose MC / 2006 / Respiratory tract mucin genes and mucin glycoproteins in health and disease / Physiol Rev 86:245~278
Sonksen P / 2000 / Insulin: Understanding its action in health and disease / Br J Anaesth 85:69~79
Zlokovic BV / 2011 / Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders / Nat Rev Neurosci 12:723~738
Rose MC / 2001 / Airway mucus obstruction: Mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia / Am J Respir Cell Mol Biol 25:533~537
Rose MC / 2006 / Respiratory tract mucin genes and mucin glycoproteins in health and disease / Physiol Rev 86:245~278
Sonksen P / 2000 / Insulin: Understanding its action in health and disease / Br J Anaesth 85:69~79
Zlokovic BV / 2011 / Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders / Nat Rev Neurosci 12:723~738
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