지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제11권 제2호
- 발행연도
- 2018.1
- 수록면
- 124 - 132 (9page)
이용수
초록· 키워드
오류제보하기
Objectives. Clusterin (CLU) is known as apolipoprotein J, and has three isoforms with different biological functions. CLU is associated with various diseases such as Alzheimer disease, atherosclerosis, and some malignancies. Recent studies report an association of CLU with inflammation and immune response in inflammatory airway diseases. However, the effect of CLU on mucin secretion of airway epithelial cells has not yet been understood. Therefore, the effect and brief signaling pathway of CLU on MUC5AC (as a major secreted mucin) expression were investigated in human airway epithelial cells. Methods. In the tissues of nasal polyp and normal inferior turbinate, the presence of MUC5AC and CLU was investigated using immunohistochemical stain and Western blot analysis. In mucin-producing human NCI-H292 airway epithelial cells and primary cultures of normal nasal epithelial cells, the effect and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway of CLU on MUC5AC expression were investigated using immunohistochemical stain, reverse transcription-polymerase chain reaction, real-time polymerase chain reaction, enzyme immunoassay, and Western blot analysis. Results. In the nasal polyps, MUC5AC and CLU were abundantly present in the epithelium on immunohistochemical stain, and nuclear CLU (nCLU) was strongly detected on Western blot analysis. In human NCI-H292 airway epithelial cells or the primary cultures of normal nasal epithelial cells, recombinant nCLU increased MUC5AC expression, and significantly activated phosphorylation of NF-κB. And BAY 11-7085 (a specific NF-κB inhibitor) and knockdown of NF-κB by NF-κB siRNA (small interfering RNA) significantly attenuated recombinant nCLU-induced MUC5AC expression. Conclusion. These results suggest that nCLU induces MUC5AC expression via the activation of NF-κB signaling pathway in human airway epithelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Pawankar R / 2007 / Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps / Curr Allergy Asthma Rep 7(3):202~208
Kim HK / 2016 / Increased expression of hCLCA1 in chronic rhinosinusitis and its contribution to produce MUC5AC / Laryngoscope 126(11):E347~E355
Ha EV / 2016 / Novel therapies to inhibit mucus synthesis and secretion in airway hypersecretory diseases / Pharmacology 97(1-2):84~100
Voynow JA / 2009 / Mucins, mucus, and sputum / Chest 135(2):505~512
Jeong S / 2012 / Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation / Am J Pathol 180(5):2028~2039
Kim HK / 2016 / Increased expression of hCLCA1 in chronic rhinosinusitis and its contribution to produce MUC5AC / Laryngoscope 126(11):E347~E355
Ha EV / 2016 / Novel therapies to inhibit mucus synthesis and secretion in airway hypersecretory diseases / Pharmacology 97(1-2):84~100
Voynow JA / 2009 / Mucins, mucus, and sputum / Chest 135(2):505~512
Jeong S / 2012 / Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation / Am J Pathol 180(5):2028~2039
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
호흡기 상피세포에서 MUC5AC와 MUC5B 발현에 대한 다중벽 탄소나노튜브의 효과
대한이비인후-두경부외과학회지
2015 .01
-
인체 호흡기 상피세포에서 고농도 인슐린에 의한 MUC4, MUC5AC, MUC5B 점액 유전자의 발현
Journal of Rhinology
2016 .01
-
사람 호흡기 상피세포에서 고농도 포도당 처치 후 활성산소를 통한 MUC5B 점액유전자 발현
대한이비인후-두경부외과학회지
2017 .01
-
Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
Clinical and Experimental Otorhinolaryngology
2019 .01
-
사람 호흡기 상피세포에서 MUC5B 발현에 대한 Polyinosinic-Polycytidylic Acid의 효과
대한이비인후-두경부외과학회지
2015 .01
-
사람 호흡기 상피세포에서 Triptolide의 Nuclear Factor-Kappa B를 통한 Lipopolysaccharide로 유도된 MUC5AC/5B 발현 억제 효과
대한이비인후-두경부외과학회지
2018 .01
-
사람 상부 호흡기 상피세포에서 황사에 의한 MUC4 점소의 과발현
대한이비인후-두경부외과학회지
2017 .01
-
인간 호흡기 상피세포에서 점액 발현에 대한 Resolvin D1과 E1의 효과
대한이비인후-두경부외과학회지
2019 .01
-
사람 호흡기 상피세포에서 Protopanaxadiol의 Lipopolysaccharide로유도된 활성산소 생성과 MUC5AC 과발현 억제 효과
대한이비인후-두경부외과학회지
2019 .01
-
Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells
Tuberculosis and Respiratory Diseases
2017 .01
-
Effect of High Glucose on MUC5B Expression in Human Airway Epithelial Cells
Clinical and Experimental Otorhinolaryngology
2017 .01
-
Changes in Mucin Production in Human Airway Epithelial Cells After Exposure to Electronic Cigarette Vapor With or Without Nicotine
Clinical and Experimental Otorhinolaryngology
2021 .08
-
사람 호흡기 상피세포에서 Peroxiredoxin 2에 의한 Lipopolysaccharide에 유도된점액 발현과 Reactive Oxygen Species 생성의 억제
대한이비인후-두경부외과학회지
2021 .12
-
Eupatilin downregulates phorbol 12‐myristate 13‐acetateinduced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells
The Korean Journal of Physiology & Pharmacology
2020 .01
-
MUC Expression in Gallbladder Epithelial Tissues in Cholesterol-Associated Gallbladder Disease
Gut and Liver
2016 .01
-
Growth Factor- and Phorbol Ester-induced Production and Gene Expression of MUC5AC Mucin in Human Airway Epithelial NCI-H292 Cells Were Inhibited by Afzelin and Natural Products Derived from Houttuynia Cordata
Natural Product Sciences
2019 .09
-
사람 호흡기 상피세포에서 Ginsenoside RB1이 TGF-β1로 유도된 MUC4/5AC 점액 유전자의 발현과 상피-중간엽 전이에 미치는 효과
대한이비인후-두경부외과학회지
2021 .01
-
Effects of Inhibiting Glycoprotein MUC5AC by Seaweed Ecklonia cava Extract in human Airway Epithelial Cells
대한의생명과학회지
2021 .12
-
인체 호흡기 상피세포에서 담배특이니트로사민에 의한 점액유전자 발현 및 기전
Journal of Rhinology
2020 .01
-
STAT3 inhibition decreases ATP-induced MUC8 gene expression in human airway epithelial cells
고신대학교 의과대학 학술지
2022 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0