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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 169 - 174 (6page)
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The placenta is an extraembryonic tissue that is formed between mother and fetus and mediates delivery of nutrients and oxygen from the mother to the fetus. Because of its essential role in sustaining the growth of the fetus during gestation, defects in its development and function frequently result in fetal growth retardation or intrauterine death, depending on its severity. Vertebrate Hox genes are well known transcription factors that are essential for the proper organization of the body plan during embryogenesis. However, certain Hox genes have been known to be expressed in placenta, implying that Hox genes not only play a crucial role during embryonic patterning but also play an important role in placental development. So far, there has been no report that shows the expression pattern of the whole Hox genes during placentation. In this study, therefore, we investigated the Hox gene expression pattern in mouse placenta, from day 10.5 to 18.5 of gestation using real-time RT-PCR method. In general, the 5" posterior Hox genes were expressed more in the developing placenta compared to the 3" Hox genes. Statistical analysis revealed that the expression of 15 Hox genes (Hoxa9, -a11, -a13/ -b8, -b9/ -c6, -c9, -c13/ -d1, -d3, -d8, -d9, -d10, -d11, -d12) were significantly changed in the course of gestation. The majority of these genes showed highest expression at gestational day 10.5, suggesting their possible role in the early stage during placental development.
목차
Acknowledgements
REFERENCES
참고문헌 (13)
참고문헌 신청
1. [학술지(정기간행물)] - Amesse LS / 2003 / Expression of HOX gene products in normal and abnormal trophoblastic tissue / Gynecol Oncol 90 : 512 ~ 518
2. [학술지(정기간행물)] - Cross JC / 2005 / How to make a placenta: mechanisms of trophoblast cell differentiation in mice / Placenta 26 (A) : 3 ~ 9
3. [학술지(정기간행물)] - Duboule D / 1994 / Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony / Dev Suppl : 135 ~ 142
4. [학술지(정기간행물)] - Gehring WJ / 1986 / Homeotic genes and the homeobox / Annu Rev Genet 20 : 147 ~ 173
5. [학술지(정기간행물)] - 김상훈 / 2011 / Effects of Dexamethasone on Embryo Development and Hox Gene Expression Patterns in Mice / 대한의생명과학회지 17 (3) : 231 ~ 238
2. [학술지(정기간행물)] - Cross JC / 2005 / How to make a placenta: mechanisms of trophoblast cell differentiation in mice / Placenta 26 (A) : 3 ~ 9
3. [학술지(정기간행물)] - Duboule D / 1994 / Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony / Dev Suppl : 135 ~ 142
4. [학술지(정기간행물)] - Gehring WJ / 1986 / Homeotic genes and the homeobox / Annu Rev Genet 20 : 147 ~ 173
5. [학술지(정기간행물)] - 김상훈 / 2011 / Effects of Dexamethasone on Embryo Development and Hox Gene Expression Patterns in Mice / 대한의생명과학회지 17 (3) : 231 ~ 238
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UCI(KEPA) : I410-ECN-0101-2013-510-002648686