지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 227 - 236 (10page)
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초록· 키워드
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Previous study showed that swimming improved obesity but was not through PPARα activation in liver and skeletal muscle in high fat diet-fed female mice with functioning ovaries as an animal model of obese premenopausal women. Thus, this study was aimed at investigation of the effects of swimming on the promotion of health and its molecular mechanism in adipose tissue of high fat diet-fed female mice. Eight-week-old female C57BL/6J mice were randomly divided into two groups (a non-swim control group and a swim group, n=8/group). Mice in the swim group swam for 2 h daily for 6 weeks in water bath with temperature of 35 ± 1℃. All the animals received high fat diet (45% kcal fat) for 6 weeks. Reverse transcription-polymerase chain reaction was used to elucidate the molecular mechanism. Female mice subjected to swimming had significantly decreased body weight gain and white adipose tissue mass compared with the female control mice. Histological studies illustrated that swimming decreases the hepatic lipid accumulation. As expected, swimming did not affect the expression of mRNA levels of peroxisome proliferator-activated receptor (PPAR) α and PPARα target genes responsible for mitochondrial fatty acid β-oxidation, such as carnitine palmitoyltransgerase-1 and medium chain acyl-CoA dehydrogenase in the white adipose tissue. However, mice that underwent 6-weeks of swimming exercise had decreased the mRNA expression of lipogenic genes, such as sterol regulatory element-binding proteins-1C and fatty acid synthase in comparison to sedentary control mice, with decreased PPARγ target genes involved in adipocyte-specific marker genes, such as adipocyte fatty acid binding protein and leptin in the white adipose tissue. These results suggest that swimming can effectively prevent obesity induced by high fat diet-fed, in part through down-regulation of adipogenesis and lipogenesis in white adipose tissue of female obese mice. Moreover, these results suggest that swimming maybe contributing the promotion of health through regulation of adipogenesis and lipogenesis in overweight premenopausal women.
목차
INTRODUCTION
MATERIALS AND METHOD
RESULTS
DISCUSSION
REFERENCES
참고문헌 (56)
참고문헌 신청
Alonso-Vale MI / 2009 / Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity / J Pineal Res 47:221~227
Auwerx J / 1996 / Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR / Atherosclerosis 124:29~37
Bertrand HA / 1978 / Increasing adipocyte number as the basis for perirenal depot growth in adult rats / Science 201:1234~1235
Bray GA. / 2003 / Risks of obesity / Endocrinol Metab Clin North Am 32:787~804
Brook GA / 1995 / Human bioenergetics and its applications / Exerc Physiol 2:151~158
Auwerx J / 1996 / Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR / Atherosclerosis 124:29~37
Bertrand HA / 1978 / Increasing adipocyte number as the basis for perirenal depot growth in adult rats / Science 201:1234~1235
Bray GA. / 2003 / Risks of obesity / Endocrinol Metab Clin North Am 32:787~804
Brook GA / 1995 / Human bioenergetics and its applications / Exerc Physiol 2:151~158
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UCI(KEPA) : I410-ECN-0101-2014-510-001368836