지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 383 - 390 (8page)
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초록· 키워드
오류제보하기
Ginseng has been used as an herbal medicine, widely used in Asian countries, for long time. Recently, beneficial effects for immune functions of Korean red ginseng (KRG) have been reported in adults. This study was performed to investigate the effects of ginseng on immune functions in children after cessation of chemotherapy or stem cell transplantation for advanced cancer. Thirty patients, who were diagnosed and treated for leukemia and solid cancer at the department of pediatrics and adolescence of the Yeungnam University Hospital from June 2004 to June 2009, were enrolled for the study. The study group consisted of 19 patients who received KRG extract (60 mg/kg/d) for 1 yr and 11 patients who did not receive KRG extract were the control group. Blood samples were collected every 6 mo. Immune assays included circulating lymphocyte subpopulation, serum cytokines (IL- 2, IL-10, IL-12, TNF-alpha, and IFN-gamma), and total concentrations of serum IgG, IgA, and IgM subclasses. Age at diagnosis ranged from 2 mo to 15 yr (median 5 yr). Nine patients received stem cell transplantation. The cytokines of the KRG treated group were decreasing more rapidly than that of the control group. Lymphocyte subpopulations (T cell, B cell, NK cell, T4, T8, and T4/T8 ratio) and serum immunoglobulin subclasses (IgG, IgA, and IgM) did not show significant differences between the study and the control groups. This study suggests that KRG extract might have a stabilizing effect on the inflammatory cytokines in children with cancer after chemotherapy.
목차
INTRODUCTION
METHODS AND MATERIALS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Mackall CL / 1994 / Lymphocyte depletion during treatment with intensive chemotherapy for cancer / Blood 84 : 2221 ~ 2228
2. [학술지(정기간행물)] - Borella L / 1971 / The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission / Cancer Res 31 : 420 ~ 426
3. [학술지(정기간행물)] - Alanko S / 1992 / Recovery of blood B-lymphocytes and serum immunoglobulins after chemotherapy for childhood acute lymphoblastic leukemia / Cancer 69 : 1481 ~ 1486
4. [학술지(정기간행물)] - Pasino M / 1981 / Immunological evaluation of 22 patients with acute lymphoblastic leukemia off-therapy / A longitudinal follow-upHelv Paediatr Acta 36 : 69 ~ 80
5. [학술지(정기간행물)] - De Vaan GA / 1982 / Recovery of immune function after cessation of maintenance therapy in acute lymphoblastic leukemia(ALL)of childhood / Eur J Pediatr 139 : 113 ~ 117
2. [학술지(정기간행물)] - Borella L / 1971 / The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission / Cancer Res 31 : 420 ~ 426
3. [학술지(정기간행물)] - Alanko S / 1992 / Recovery of blood B-lymphocytes and serum immunoglobulins after chemotherapy for childhood acute lymphoblastic leukemia / Cancer 69 : 1481 ~ 1486
4. [학술지(정기간행물)] - Pasino M / 1981 / Immunological evaluation of 22 patients with acute lymphoblastic leukemia off-therapy / A longitudinal follow-upHelv Paediatr Acta 36 : 69 ~ 80
5. [학술지(정기간행물)] - De Vaan GA / 1982 / Recovery of immune function after cessation of maintenance therapy in acute lymphoblastic leukemia(ALL)of childhood / Eur J Pediatr 139 : 113 ~ 117
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UCI(KEPA) : I410-ECN-0101-2014-524-001184436