지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 42 - 49 (8page)
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초록· 키워드
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In this study, we have investigated the effect of Korean red ginseng (KRG) extracts on the production of TNF-α and IL-8 in human keratinocytes. Also, to examine the antioxidative effect of red ginseng extracts, free radical scavenging activity and superoxide dismutase (SOD) activity in human dermal fibroblasts was measured. Methods: To investigate the effect of KRG in atopic dermatitis, we measured the level of TNF-α and IL-8 secretion in LPS-stimulated human keratinocytes after the treatment of KRG extracts using enzyme-linked immunosorbent assay. Anti-oxidative activity was investigated by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and SOD activity. Results: The stimulation of human keratinocytes with KRG extracts shifted the LPS-induced cytokine secretion toward a more immunosuppressive response. KRG dose-dependently decreased TNF-α and IL-8 production in HaCaT cells and a significant inhibition of TNF-α was shown when cells were treated with 500 and 1,000μg/ml of KRG extracts. Additionally, KRG extracts showed DPPH radical scavenging and SOD activity in a dose-dependent manner. Particularly, SOD activities of concentrations higher than 60μg/ml of KRG extracts were significantly different in human dermal fibroblast cells. Conclusion: Based on this study, KRG extracts may be a useful immunosuppressive agent in the treatment of atopic dermatitis.
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참고문헌 (47)
참고문헌 신청
Williams H / 2008 / International Study of Asthma and Allergies in Childhood (ISAAC) Phase One and Three Study Groups: Is eczema really on the increase worldwide / J Allergy Clin Immunol 121:947~954
Jonathan M / 2010 / From atopic dermatitis to asthma: the atopic march / Ann Allergy Asthma Immunol 105:99~106
Spergel JM / 2003 / Atopic dermatitis and the atopic march / J Allergy Clin Immunol 112(6):S118~S127
Homey B / 2006 / Cytokines and chemokines orchestrate atopic skin inflammation / J Allergy Clin Immunol 118:178~189
Pivarcsi A / 2005 / Innate immunity in the skin: how keratinocytes fight against pathogens / Current Immunology 1:29~42
Jonathan M / 2010 / From atopic dermatitis to asthma: the atopic march / Ann Allergy Asthma Immunol 105:99~106
Spergel JM / 2003 / Atopic dermatitis and the atopic march / J Allergy Clin Immunol 112(6):S118~S127
Homey B / 2006 / Cytokines and chemokines orchestrate atopic skin inflammation / J Allergy Clin Immunol 118:178~189
Pivarcsi A / 2005 / Innate immunity in the skin: how keratinocytes fight against pathogens / Current Immunology 1:29~42
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