지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Assessment was made of the effects of Aralia cordata Thunb (DH) on the cell proliferation, inducible nitric oxide synthase (iNOS) mRNA gene expression and nitric oxide (NO) production in RAW 264.7 macrophage cells. For the screening of anti-inflammatory activities, ethanolic extracts of 55 species of traditional herbal medicines were examined for inhibitory effects, and it was confirmed that DH possessed inhibitory effects on NO production. As a result, DH significantly decreased the production of NO and iNOS gene expression at a concentration of 250 μg/mL. The chloroformsoluble fractionates have the strongest No synthesis inhibitory effect. It is presumed that the inhibition of NO production in LPS-stimulated RAW 264.7 cells by DH components occurred via the modulation of iNOS and DH, and that the active compound from DH may be useful for therapeutic management of inflammatory-associate diseases.
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Abstract
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재료 및 방법
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참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Stuehr DJ / 1991 / Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein / P. Natl. Acad. Sci. USA 88 : 7773 ~ 7777
2. [학술지(정기간행물)] - 이화진 / 199903 / A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages / PLANTA MEDICA 65 (2) : 104 ~ 108
3. [학술지(정기간행물)] - Busse R / 1990 / Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells / FEBS Lett 275 : 87 ~ 90
4. [학술지(정기간행물)] - Bravo MJ / 1992 / The role of attention in different visualsearch tasks / Percept. Psychophys 51 : 465 ~ 472
5. [학술지(정기간행물)] - Werner-Felmayer G / 1990 / Reibnegger G, Wachter H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts / J. Exp. Med 172 : 1599 ~ 1607
2. [학술지(정기간행물)] - 이화진 / 199903 / A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages / PLANTA MEDICA 65 (2) : 104 ~ 108
3. [학술지(정기간행물)] - Busse R / 1990 / Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells / FEBS Lett 275 : 87 ~ 90
4. [학술지(정기간행물)] - Bravo MJ / 1992 / The role of attention in different visualsearch tasks / Percept. Psychophys 51 : 465 ~ 472
5. [학술지(정기간행물)] - Werner-Felmayer G / 1990 / Reibnegger G, Wachter H. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts / J. Exp. Med 172 : 1599 ~ 1607
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UCI(KEPA) : I410-ECN-0101-2014-573-001113089