지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: The purpose of this study was to investigate the effects of Angelicae pubescentis Radix water extract(ACE) on immune properties in macrophage cells.
Methods: The cells were divided into two groups: As a control, the first was not treated with ACE, and the other was treated with ACE. Together with the cell viability, productions of nitric oxide (NO) and cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α by treating of ACE were monitored.
Results:
1. There was no decrease of the cell viability after 24 hr incubation, but a significant decrease after 48 hr incubation with all four concentrations (25, 100, 200, and 400 ㎍/㎖) of ACE.
2. A significant increase in the production of NO was observed in the concentrations above 50 ㎍/㎖ of ACE after 24 hr incubation.
3. Further, after 48 hr incubation, the critical concentration of ACE for the increase was reduced to 25 ㎍/㎖.
4. The production of IL-1β significantly increased with the ACE concentrations of 100 and 200 ㎍/㎖ after 24 hr incubation.
5. The production of IL-6 significantly increased with the ACE concentration of 200 ㎍/㎖ after 24 hr incubation.
6. A significant increase in the production of TNF-α was detected with ACE concentrations of 50, 100, and 200 ㎍/㎖ after 24 hr incubation
Conclusions: These show that ACE increases mouse macrophage NO production at concentrations above 50 ㎍/㎖, and the cytokines (IL-1β, IL-6, and TNF-α) at concentrations above 200 ㎍/㎖. These results suggest that ACE improves macrophage immune property.
Methods: The cells were divided into two groups: As a control, the first was not treated with ACE, and the other was treated with ACE. Together with the cell viability, productions of nitric oxide (NO) and cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α by treating of ACE were monitored.
Results:
1. There was no decrease of the cell viability after 24 hr incubation, but a significant decrease after 48 hr incubation with all four concentrations (25, 100, 200, and 400 ㎍/㎖) of ACE.
2. A significant increase in the production of NO was observed in the concentrations above 50 ㎍/㎖ of ACE after 24 hr incubation.
3. Further, after 48 hr incubation, the critical concentration of ACE for the increase was reduced to 25 ㎍/㎖.
4. The production of IL-1β significantly increased with the ACE concentrations of 100 and 200 ㎍/㎖ after 24 hr incubation.
5. The production of IL-6 significantly increased with the ACE concentration of 200 ㎍/㎖ after 24 hr incubation.
6. A significant increase in the production of TNF-α was detected with ACE concentrations of 50, 100, and 200 ㎍/㎖ after 24 hr incubation
Conclusions: These show that ACE increases mouse macrophage NO production at concentrations above 50 ㎍/㎖, and the cytokines (IL-1β, IL-6, and TNF-α) at concentrations above 200 ㎍/㎖. These results suggest that ACE improves macrophage immune property.
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UCI(KEPA) : I410-ECN-0101-2014-519-000285137