지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 413 - 419 (7page)
이용수
초록· 키워드
오류제보하기
The melanoma differentiation-associated gene-7 (MDA-7) protein, also known as interleukin-24 (IL-24), is a novel candidate of tumor suppressor that can induce apoptosis experimentally in a variety of human malignant cells. However, there have been few studies about its role in colorectal cancer. We performed immunohistochemical detection of MDA-7/ IL-24 in 399 tissue samples from primary colorectal adenocarcinoma patients using a tissue microarray. Western blotting was then done to confirm the immunohistochemical observations. MDA-7/IL-24 immunoreactivity was observed in 116 (29.1%) of the 399 colorectal adenocarcinoma cases. Analysis of the MDA-7/IL-24 expression by Western blotting confirmed the immunohistochemical results. The tumors with a negative MDA-7/IL-24 expression more frequently showed poor differentiation (P=0004), lymph node metastasis (P=0.001), deep invasion (P=0.008) and high stage (P=0.001). A subset of colorectal adenocarcinoma revealed a decreased expression of MDA-7/IL-24, and this was associated with progressive pathologic features. These findings suggest that loss of MDA-7/IL-24 expression may play a role in tumor growth and progression of colorectal adenocarcinomas.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (27)
참고문헌 신청
American Joint Committee on Cancer / 2010 / AJC cancer staging manual.7th edition / Springer
Bosman FT / 2010 / WHO classification of tumours of the digestive system / IARC Press
Chada S / 2006 / Mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members / Cancer Gene Ther 13:490~502
2011 / Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer / WORLD JOURNAL OF GASTROENTEROLOGY 17(9):1167~1173
Cunningham CC / 2005 / Clinical and local biological effects of and intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study / Mol Ther 11:149~159
Bosman FT / 2010 / WHO classification of tumours of the digestive system / IARC Press
Chada S / 2006 / Mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members / Cancer Gene Ther 13:490~502
2011 / Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer / WORLD JOURNAL OF GASTROENTEROLOGY 17(9):1167~1173
Cunningham CC / 2005 / Clinical and local biological effects of and intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study / Mol Ther 11:149~159
이 논문의 저자 정보
이 논문과 함께 이용한 논문
휜의 피치 및 배열 방식에 따른 프리히터의 전열 성능에 관한 연구
유지훈
,
김귀순
한국유체기계학회 논문집
2013
.12
터보팬 엔진 고압터빈 노즐에 대한 크리깅 모델 기반 근사모델의 신뢰도 및 공력성능 최적화 연구
이상아
,
이세일
,
강영석
외 3명
한국유체기계학회 논문집
2013
.12
스팀 터빈 블레이드 원심응력 추정을 위한 전산해석 연구
이병학
,
박종호
한국유체기계학회 논문집
2013
.12
팁간극높이가 전면스퀼러팁 표면의 열전달 특성에 미치는 영향
강동범
,
문현석
,
이상우
한국유체기계학회 논문집
2013
.12
원심블로어 임펠러 토출 날개 형상에 따른 성능특성
이종성
,
전현준
,
장춘만
한국유체기계학회 논문집
2013
.12
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-000614382