지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 420 - 427 (8page)
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Sprague-Dawley (SD) rats were orally administered with NG-nitro-L-arginine methyl ester (L-NAME), which inhibits or blocks the production of nitric oxide from L-arginine in vascular endothelial cells and vessel tissue. We examined the effects of nitric oxide on some physiological changes such as blood pressure and heart rate, and confirms the apoptosis induced by the suppressed nitric oxide activity in the kidney. This study was performed to investigate correlation between the activities of nitric oxide and apoptosis by immunohistochemical changes of apoptotic control proteins with regulated chronic inhibition of nitric oxide. In the kidney from L-NAME-treated group, immunohistochemical reaction to the antigens of apoptosis inhibiting proteins such as bcl-2 and bcl-xL, exhibited a time-dependent reduction. The expression of apoptosis-inhibiting proteins such as bax and p53 increased expression in proportion to the duration of treatment. The most sensitive apoptosis regulating proteins to L-NAME were p53 in stimulation and bcl-2 in inhibition, respectively.
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REFERENCES
참고문헌 (32)
참고문헌 신청
Amore A / 2000 / Nitric oxide mediate cyclosporine-induced apoptosis in cultured renal cells / Kidney Int 57:1549~1559
Antonsson B. / 2004 / Mitochondria and the bcl-2 family proteins in apoptosis signaling pathways / Mol Cell Biochem 256:141~155
Brune B / 1999 / Nitric oxide (NO): an effector of apoptosis / Cell Death Differ 6:969~975
Bursch W / 1985 / Quantiative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia / Virchows Arch B Cell Pathol Incl Mol Pathol 50:153~166
Cotran R / 1994 / Pathologic basis of disease. 5th ed / WB Saunders Co :17~21
Antonsson B. / 2004 / Mitochondria and the bcl-2 family proteins in apoptosis signaling pathways / Mol Cell Biochem 256:141~155
Brune B / 1999 / Nitric oxide (NO): an effector of apoptosis / Cell Death Differ 6:969~975
Bursch W / 1985 / Quantiative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia / Virchows Arch B Cell Pathol Incl Mol Pathol 50:153~166
Cotran R / 1994 / Pathologic basis of disease. 5th ed / WB Saunders Co :17~21
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UCI(KEPA) : I410-ECN-0101-2014-510-000614397