지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 241 - 248 (8page)
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초록· 키워드
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Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the expression of matrix metalloproteinase (MMP) and decrease collagen synthesis in human skin cells. In this study, we examined the anti-photoaging effects of extracts of Tetraselmis suecica (W-TS). W-TS showed the strongest scavenging activity against 2,2-difenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals, followed by superoxide anions from the xanthine/xanthine oxidase system. We observed that the levels of both intracellular ROS and lipid peroxidation significantly increased in UVB-irradiated human skin fibroblast cells. Furthermore, the activities of enzymatic antioxidants (e.g., superoxide dismutase) and the levels of non-enzymatic antioxidants (e.g., glutathione) significantly decreased in cells. However, W-TS pretreatment, at the maximum tested concentration, significantly decreased intracellular ROS and malondialdehyde (MDA) levels, and increased superoxide dismutase and glutathione levels in the cells. At this same concentration, W-TS did not show cytotoxicity. Type 1 procollagen and MMP-1 released were quantified using RT-PCR techniques. The results showed that W-TS protected type 1 procollagen against UVBinduced depletion in fibroblast cells in a dose-dependent manner via inhibition of UVB-induced MMP-1. Taken together, the results of the study suggest that W-TS effectively inhibits UVB-induced photoaging in skin fibroblasts by its strong anti-oxidant ability.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Afaq, F / 2006 / Botanical antioxidants in the prevention of photocarcinogenesis and photoaging / Exp. Dermatol 15:678~684
Berson, D.S / 2008 / Natural antioxidants / J. Drugs Dermatol 7:7~12
Brand-Williams, W / 1995 / Use of a free radical method to evaluate antioxidant activity / LWTFood Sci. Technol 28:25~30
Brown, M. R. / 1991 / The amino-acid and sugar composition of 16 species of microalgae used in mariculture / J. Exp. Mar. Biol. Ecol 145:79~99
Brown, M.R / 1999 / The vitamin content of microalgae used in aquaculture / J. Appl. Phycol 11:247~255
Berson, D.S / 2008 / Natural antioxidants / J. Drugs Dermatol 7:7~12
Brand-Williams, W / 1995 / Use of a free radical method to evaluate antioxidant activity / LWTFood Sci. Technol 28:25~30
Brown, M. R. / 1991 / The amino-acid and sugar composition of 16 species of microalgae used in mariculture / J. Exp. Mar. Biol. Ecol 145:79~99
Brown, M.R / 1999 / The vitamin content of microalgae used in aquaculture / J. Appl. Phycol 11:247~255
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UCI(KEPA) : I410-ECN-0101-2014-513-000614610