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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study was carried out to know the effects of Gwan-Jul-Bang-7 (hereafter referred to GJB-7) on the inhibition of arthritis induced by collagen on the mouse.
Methods: To assess the effects of GJB-7 on mouse with arthritis induced by collagen Ⅱ, we conducted several experiments such as analysis of cytotoxicity, hepatotoxicity, arthritis index, total cell number of draining lymph nodes and paw joints, value of immunocyte in PBMC (peripheral blood mononuclear cell), DLN (draining lymph node) and paw joint, measurement of cytokine and anti-collagen Ⅱ, observation of the histological changes of joint.
Results:
1. Cytotoxicity against HFC (human fibroblast cells) was not observed in any concentration and hepatotoxicity was not observed in the GJB-7 treated group.
2. The incidence of arthritis significantly decreased.
3. Total cell number of draining lymph nodes significantly increased and total cell number of paw joints significantly decreased.
4. The percentage of CD8<SUP>+</SUP> cells in PBMC (peripheral blood mononuclear cell) significantly increased. The percentage of CD3<SUP>+</SUP>/CD69<SUP>+</SUP>, and CD3<SUP>+</SUP>/CD49b<SUP>+</SUP> cells in PBMC significantly decreased.
5. The percentage of CD19<SUP>+</SUP>, CD3<SUP>+</SUP>, and CD4<SUP>+</SUP>/CD25<SUP>+</SUP> cells in DLN (draining lymph nodes) significantly increased. The percentage of B220<SUP>+</SUP>/ CD23<SUP>+</SUP> cells in DLN significantly decreased.
6. The percentage of CD3<SUP>+</SUP>, CD4<SUP>+</SUP>, and CD11b<SUP>+</SUP>/Gr-1<SUP>+</SUP> cells in paw joints significantly decreased.
7. The production of TNF-α, IL-6, and MCP-1 significantly decreased.
8. Anti-collagen Ⅱ in serum significantly decreased.
9. With the hematoxylin and eosin stain, inflammation of joint decreased. Under Masson"s trichrome stain, the cartilage destruction and synovial cell proliferation and the expression of collagen fibers decreased.
Conclusions: Comparison of the results for this study showed that GJB-7 had immunomodulatory effects. So we expect that GJB-7 could be used as an effective drug for not only rheumatoid arthritis but also another auto-immune diseases.
Methods: To assess the effects of GJB-7 on mouse with arthritis induced by collagen Ⅱ, we conducted several experiments such as analysis of cytotoxicity, hepatotoxicity, arthritis index, total cell number of draining lymph nodes and paw joints, value of immunocyte in PBMC (peripheral blood mononuclear cell), DLN (draining lymph node) and paw joint, measurement of cytokine and anti-collagen Ⅱ, observation of the histological changes of joint.
Results:
1. Cytotoxicity against HFC (human fibroblast cells) was not observed in any concentration and hepatotoxicity was not observed in the GJB-7 treated group.
2. The incidence of arthritis significantly decreased.
3. Total cell number of draining lymph nodes significantly increased and total cell number of paw joints significantly decreased.
4. The percentage of CD8<SUP>+</SUP> cells in PBMC (peripheral blood mononuclear cell) significantly increased. The percentage of CD3<SUP>+</SUP>/CD69<SUP>+</SUP>, and CD3<SUP>+</SUP>/CD49b<SUP>+</SUP> cells in PBMC significantly decreased.
5. The percentage of CD19<SUP>+</SUP>, CD3<SUP>+</SUP>, and CD4<SUP>+</SUP>/CD25<SUP>+</SUP> cells in DLN (draining lymph nodes) significantly increased. The percentage of B220<SUP>+</SUP>/ CD23<SUP>+</SUP> cells in DLN significantly decreased.
6. The percentage of CD3<SUP>+</SUP>, CD4<SUP>+</SUP>, and CD11b<SUP>+</SUP>/Gr-1<SUP>+</SUP> cells in paw joints significantly decreased.
7. The production of TNF-α, IL-6, and MCP-1 significantly decreased.
8. Anti-collagen Ⅱ in serum significantly decreased.
9. With the hematoxylin and eosin stain, inflammation of joint decreased. Under Masson"s trichrome stain, the cartilage destruction and synovial cell proliferation and the expression of collagen fibers decreased.
Conclusions: Comparison of the results for this study showed that GJB-7 had immunomodulatory effects. So we expect that GJB-7 could be used as an effective drug for not only rheumatoid arthritis but also another auto-immune diseases.
목차
서론
실험
성적
고찰
결론
참고문헌
참고문헌 (42)
참고문헌 신청
1. [단행본] - 대한 정형외과학회 / 2001 / 정형외과학 / 최신의학사 : 123 ~ 189
2. [단행본] - 해리슨 번역 편찬위원회 / 2006 / 해리슨 내과학 / 정담출판사 : 78 ~ 99
3. [학술지(정기간행물)] - Chin N. Tran / 2005 / Synovial biology and T cell in rheumatoid arthritis / Pathophysiology 12 (3) : 183 ~ 189
4. [단행본] - 김기현 / 1993 / 痺證 / 정담출판사 : 23 ~ 29
5. [단행본] - Hwang DS / 2005 / Effects of Kagammokbanggi-tang on the Adjuvant-induced arthritis in rats / Semyung university graduate school
2. [단행본] - 해리슨 번역 편찬위원회 / 2006 / 해리슨 내과학 / 정담출판사 : 78 ~ 99
3. [학술지(정기간행물)] - Chin N. Tran / 2005 / Synovial biology and T cell in rheumatoid arthritis / Pathophysiology 12 (3) : 183 ~ 189
4. [단행본] - 김기현 / 1993 / 痺證 / 정담출판사 : 23 ~ 29
5. [단행본] - Hwang DS / 2005 / Effects of Kagammokbanggi-tang on the Adjuvant-induced arthritis in rats / Semyung university graduate school
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UCI(KEPA) : I410-ECN-0101-2014-519-000283991