지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : This study was carried out to find the effects of Changchuldoin-tanggamibang (hereinafter referred to CDIT) on the inhibition of arthritis induced by collagen on DBA/1J mouse.
Methods : The experimental mice were divided into four groups: normal group (Nr), control group (CIA-CT), methotrexate group (CIA-MTX), and Changchuldoin-tanggamibang group (CIA-CDIT). Cytotoxicity, hepatotoxicity, arthritis index, value of immunocytes in draining lymph node and paw joint, and rheumatoid factor (IgG, IgM) in serum were measured in vivo.
Results :
1. Cytotoxicity against hFCs was not shown in any concentration.
2. Hepatotoxicity was low in the CDIT-treated group compared with the MTX group.
3. The arthritis index decreased significantly.
4. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was a significant decrease in paw joint.
5. In lymph nodes, CD19+, CD3+, CD4+, CD8+, CD3+/CD8+, CD3+/CD69+, CD4+/CD25+, CD3+/CD49b+, and CD4+/CD44+ cells increased significantly, while B220+/CD23+, and CD11c+/MHCⅡ+ cells decreased significantly.
6. In joints, CD3+, CD4+, CD4+/CD25+, and CD11b+/Gr-1+ cells decreased significantly.
7. The level of IgG decreased and the level of IgM significantly decreased compared with the control.
8. Anti-collagen Ⅱ in serum decreased compared with the control.
9. Around the joint of the CDIT group, infiltration of inflammation, synovial hyperplasia, invasion of cytokine,of cartilage, deposition of collagen and synovial injury decreased compared with the control in histopathologic observation (HE, MT staining).
Conclusions : Comparison of the results for this study showed that CDIT had immunomodulatory effects. We expect that CDIT could be used as a effective drug for not only rheumatoid arthritis but also another auto-immune diseases. Therefore, we have to survey continuously, looking for effective substances and mechanisms in the future.
Methods : The experimental mice were divided into four groups: normal group (Nr), control group (CIA-CT), methotrexate group (CIA-MTX), and Changchuldoin-tanggamibang group (CIA-CDIT). Cytotoxicity, hepatotoxicity, arthritis index, value of immunocytes in draining lymph node and paw joint, and rheumatoid factor (IgG, IgM) in serum were measured in vivo.
Results :
1. Cytotoxicity against hFCs was not shown in any concentration.
2. Hepatotoxicity was low in the CDIT-treated group compared with the MTX group.
3. The arthritis index decreased significantly.
4. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was a significant decrease in paw joint.
5. In lymph nodes, CD19+, CD3+, CD4+, CD8+, CD3+/CD8+, CD3+/CD69+, CD4+/CD25+, CD3+/CD49b+, and CD4+/CD44+ cells increased significantly, while B220+/CD23+, and CD11c+/MHCⅡ+ cells decreased significantly.
6. In joints, CD3+, CD4+, CD4+/CD25+, and CD11b+/Gr-1+ cells decreased significantly.
7. The level of IgG decreased and the level of IgM significantly decreased compared with the control.
8. Anti-collagen Ⅱ in serum decreased compared with the control.
9. Around the joint of the CDIT group, infiltration of inflammation, synovial hyperplasia, invasion of cytokine,of cartilage, deposition of collagen and synovial injury decreased compared with the control in histopathologic observation (HE, MT staining).
Conclusions : Comparison of the results for this study showed that CDIT had immunomodulatory effects. We expect that CDIT could be used as a effective drug for not only rheumatoid arthritis but also another auto-immune diseases. Therefore, we have to survey continuously, looking for effective substances and mechanisms in the future.
목차
서론
실험
성적
고찰
결론
참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Kipnis J / 2002 / Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system / The National Academy of Sciences 99 (24) : 15620 ~ 15625
2. [학술지(정기간행물)] - Charbonnier LM / 2006 / Immature dendritic cell suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cell / J Immunol 177 (6) : 3806 ~ 3813
3. [학술지(정기간행물)] - Rosenwasser LJ / 2003 / Allergic asthma and an anti-CD23 mAb(IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial / J Allergy Clin Immunnol 112 (3) : 563 ~ 570
4. [학술지(정기간행물)] - Gavin MA / 2002 / Homeostasis and anergy of CD4+/CD25+ suppressor T cells in vivo / Nat Immunol 3 (1) : 33 ~ 41
5. [단행본] - Mosby internatiional Ltd / 2000 / Crash Couse. Immune blood and Lymphatic Systems / Hanwoori : 17 ~ 21
2. [학술지(정기간행물)] - Charbonnier LM / 2006 / Immature dendritic cell suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cell / J Immunol 177 (6) : 3806 ~ 3813
3. [학술지(정기간행물)] - Rosenwasser LJ / 2003 / Allergic asthma and an anti-CD23 mAb(IDEC-152): results of a phase I, single-dose, dose-escalating clinical trial / J Allergy Clin Immunnol 112 (3) : 563 ~ 570
4. [학술지(정기간행물)] - Gavin MA / 2002 / Homeostasis and anergy of CD4+/CD25+ suppressor T cells in vivo / Nat Immunol 3 (1) : 33 ~ 41
5. [단행본] - Mosby internatiional Ltd / 2000 / Crash Couse. Immune blood and Lymphatic Systems / Hanwoori : 17 ~ 21
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UCI(KEPA) : I410-ECN-0101-2014-519-000285379