지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : It has been reported that Polygonati rhizoma (Pr) has anti-hyperglycemia, anti-triglycemia, anti-diabetic, and anti-tumor activity. Total extract of Pr was tested to identify anti-adipogenic activity in 3T3-L1 differentiation and molecular mechanism of Pr in 3T3-L1 differentiation.
Methods : Differentiation of 3T3-L1 pre-adipocyte was induced in the presence of Pr extract and kaempferol. The level of lipid accumulation was measured by Oil Red O staining. The expression of genes associated with adipocyte differentiation was measured by RT-PCR.
Results : Extract of Pr and its component kaempferol reduced lipid accumulation in 3T3-L1 during adipogenesis and also reduced mRNA levels of genes associated with adipogenesis, such as adipsin, aP2, LPL, SERBP-1c and PPARγ. Conclusions: In this study, we showed that the molecular mechanism of Pr and kaempferol activity is related to regulation of PPARγ expression and activation.
Methods : Differentiation of 3T3-L1 pre-adipocyte was induced in the presence of Pr extract and kaempferol. The level of lipid accumulation was measured by Oil Red O staining. The expression of genes associated with adipocyte differentiation was measured by RT-PCR.
Results : Extract of Pr and its component kaempferol reduced lipid accumulation in 3T3-L1 during adipogenesis and also reduced mRNA levels of genes associated with adipogenesis, such as adipsin, aP2, LPL, SERBP-1c and PPARγ. Conclusions: In this study, we showed that the molecular mechanism of Pr and kaempferol activity is related to regulation of PPARγ expression and activation.
목차
서론
재료 및 방법
성적
고찰
결론
참고문헌
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Lin J / 2005 / Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes / Obes Res 13 (6) : 982 ~ 990
2. [학술지(정기간행물)] - Pinent M / 2005 / Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation / Int J Obes (Lond). 29 (8) : 934 ~ 941
3. [학술지(정기간행물)] - Hassan M / 2007 / Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells / Biochem Biophys Res Commun 361 (1) : 208 ~ 213
4. [학술지(정기간행물)] - Kim JB / 1996 / Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism / Genes Dev 10 (9) : 1096 ~ 1107
5. [학술지(정기간행물)] - Brun RP / 1996 / Adipocyte differentiation: a transcriptional regulatory cascade / Curr Opin Cell Biol 8 (6) : 826 ~ 832
2. [학술지(정기간행물)] - Pinent M / 2005 / Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation / Int J Obes (Lond). 29 (8) : 934 ~ 941
3. [학술지(정기간행물)] - Hassan M / 2007 / Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells / Biochem Biophys Res Commun 361 (1) : 208 ~ 213
4. [학술지(정기간행물)] - Kim JB / 1996 / Spiegelman BM. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism / Genes Dev 10 (9) : 1096 ~ 1107
5. [학술지(정기간행물)] - Brun RP / 1996 / Adipocyte differentiation: a transcriptional regulatory cascade / Curr Opin Cell Biol 8 (6) : 826 ~ 832
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
폐암세포주에서 黃精의 주요 성분인 Kaempferol의 항암 효능
동의생리병리학회지
2011 .10
-
폐암세포주에서 황정(黃精)의 주요 성분인 Kaempferol의 항암 효능
동의생리병리학회지
2011 .01
-
황정(黃精)과 증숙 황정(蒸熟 黃精)의 항산화, 항피로 효능 비교 연구
대한본초학회지(본초분과학회지)
2016 .01
-
간암 세포주에서 黃精의 주요 성분인 Kaempferol의 성장 억제 효과
동의생리병리학회지
2012 .08
-
간암 세포주에서 황정(黃精)의 주요 성분인 Kaempferol의 성장 억제 효과
동의생리병리학회지
2012 .01
-
Kaempferol 및 Kaempferol Rhamnosides의 항산화 활성 및 항염 효과에 관한 연구
대한화장품학회지
2011 .01
-
Effects of Polygonati Rhizoma Extracts on the Collagenase Activity and Procollagen Synthesis in Hs68 Human Fibroblasts and Tyrosinase Activity
대한본초학회지(본초분과학회지)
2013 .01
-
Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models
Toxicological Research
2013 .12
-
Quality control of Polygonati Rhizoma
대한약학회 학술대회
2000 .01
-
The Effects of the 3-OH Group of Kaempferol on Interfollicular Epidermal Stem Cell Fate
Annals of Dermatology
2018 .01
-
Repression of PPARγ Activity on Adipogenesis by 17β-estradiol in Differentiated 3T3-L1 Cell
대한의생명과학회지
2009 .09
-
Biphasic Effects of Kaempferol on the Estrogenicity in Human Breast Cancer Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Kaempferol이 LPS로 유도된 생쥐 중추신경계 염증에 미치는 영향
대한본초학회지(본초분과학회지)
2015 .01
-
黃精이 흰쥐의 식이성 고지혈증에 미치는 영향
동의생리병리학회지
2008 .10
-
홍화의 후라보노이드 성분
약학회지
1992 .01
-
천궁(川芎)의 정유 추출물이 3T3-L1 세포의 분화 및 지방 생성에 미치는 영향
한방재활의학과학회지
2018 .01
-
증숙 황정 물 추출물의 항산화 활성
대한본초학회지(본초분과학회지)
2017 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
고기능성 들깻잎을 이용한 침출차의 품질 극대화를 위한 최적 볶음조건 연구
윤웅재
,
양성용
,
이현순
외 2명
한국식품과학회지
2012
.02
Global Gene Expression Changes by Several Phytochemicals in Human Colorectal Cancer Cell
Min-Hee Pa
,
k
,
Eun Hee Kwak
외 3명
생명과학회지
2011
.09
RAW264.7 Macrophage Cell에서 녹차씨껍질 에틸아세테이트 분획의 염증억제 효과 및 기전 연구
노경희
,
장지현
,
민관희
외 3명
한국식품영양과학회지
2011
.05
개똥쑥의 항산화 및 항암활성과 기능성 물질의 탐색
류지현
,
이수정
,
김미주
외 4명
한국식품영양과학회지
2011
.04
곰취차로부터 라디칼 소거능을 갖는 Caffeoylquinic Acid류 화 합물의 추출조건
김상민
,
강석우
,
엄병헌
한국식품영양과학회지
2010
.03
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000285495