지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective: Leejung-tang (Rechu-to in Japanese) is a traditional Korean herbal formula used for treatment of gastrointestinal disorders such as vomiting, stomach pain, chronic gastritis and gastrointestinal ulceration. The present study was carried out to investigate the potential acute toxicity of Leejung-tang water extract (LJT) by a single oral dose in Crl:CD (SD) rats in compliance with current guidelines.
Methods: In the preliminary study, there were no adverse effects such as death, clinical signs, and body weight changes at dose levels of 500, 1000, and 2000 ㎎/㎏/day body weight. Based on the results, a dose of 2000 ㎎/㎏ was selected as the toxicological limited dose. LJT was administered once by gavage to male and female rats at dose levels of 0 and 2000 ㎎/㎏ bodyweight. During the study period, mortalities, clinical findings, and body weight changes were observed for 14 days following the administration. On day 14 after the treatment, the animals were sacrificed by carbon dioxide overdose and complete gross postmortem examinations were performed.
Results: In present study, no treatment-related deaths were observed. There were no adverse effects on clinical signs and body weight changes. In addition, there were no observed gross findings in all groups except for a kidney cyst in the 2000 ㎎/㎏/day female group.
Conclusion: The results indicated that LJT did not induce toxic effects at a dose level up to 2000 ㎎/㎏ in rats and its median lethal dose (LD50) was considered to be over 2000 ㎎/㎏/day body weight for both genders.
Methods: In the preliminary study, there were no adverse effects such as death, clinical signs, and body weight changes at dose levels of 500, 1000, and 2000 ㎎/㎏/day body weight. Based on the results, a dose of 2000 ㎎/㎏ was selected as the toxicological limited dose. LJT was administered once by gavage to male and female rats at dose levels of 0 and 2000 ㎎/㎏ bodyweight. During the study period, mortalities, clinical findings, and body weight changes were observed for 14 days following the administration. On day 14 after the treatment, the animals were sacrificed by carbon dioxide overdose and complete gross postmortem examinations were performed.
Results: In present study, no treatment-related deaths were observed. There were no adverse effects on clinical signs and body weight changes. In addition, there were no observed gross findings in all groups except for a kidney cyst in the 2000 ㎎/㎏/day female group.
Conclusion: The results indicated that LJT did not induce toxic effects at a dose level up to 2000 ㎎/㎏ in rats and its median lethal dose (LD50) was considered to be over 2000 ㎎/㎏/day body weight for both genders.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Kwak KH / 1987 / Experimental studies on the effects of Yijoongtang and Daeseunggitang / K.H.Univ. O. Med. J 10 : 505 ~ 529
2. [학술지(정기간행물)] - Ha JY / 1998 / Experiment on the antitumor and immunomodulatory effects of Gagamijungtang in BALB/c mice / Korean J Oriental Medical Pathology 12 (2) : 73 ~ 81
4. [학술지(정기간행물)] - 서희연 / 2009 / 理中湯이 IgE가 과잉생성되고 피부염이 유발된 NC/Nga생쥐에서 IFN-γ 반응에 의한 Th2 세포분화 억제에 미치는 영향 / 대한한방소아과학회지 23 (1) : 1 ~ 22
5. [학술지(정기간행물)] - 마진열 / 2007 / ICR마우스를 이용하여 八物湯의 급성독성에 관한 연구 / 대한본초학회지 22 (2) : 13 ~ 16
6. [학술지(정기간행물)] - Ma JY / 2007 / Acute toxicity study on SsangHwaTang in mice / J Korean Oriental Med 13 : 161 ~ 164
2. [학술지(정기간행물)] - Ha JY / 1998 / Experiment on the antitumor and immunomodulatory effects of Gagamijungtang in BALB/c mice / Korean J Oriental Medical Pathology 12 (2) : 73 ~ 81
4. [학술지(정기간행물)] - 서희연 / 2009 / 理中湯이 IgE가 과잉생성되고 피부염이 유발된 NC/Nga생쥐에서 IFN-γ 반응에 의한 Th2 세포분화 억제에 미치는 영향 / 대한한방소아과학회지 23 (1) : 1 ~ 22
5. [학술지(정기간행물)] - 마진열 / 2007 / ICR마우스를 이용하여 八物湯의 급성독성에 관한 연구 / 대한본초학회지 22 (2) : 13 ~ 16
6. [학술지(정기간행물)] - Ma JY / 2007 / Acute toxicity study on SsangHwaTang in mice / J Korean Oriental Med 13 : 161 ~ 164
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UCI(KEPA) : I410-ECN-0101-2014-519-000281280