지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 281 - 286 (6page)
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초록· 키워드
오류제보하기
Helminthic infections afflict over 1.5 billion people worldwide, while Mycobacterium tuberculosis infects one third of the world’s population, resulting in 2 million deaths per year. Although tuberculosis and helminthic infections coexist in many parts of the world, and it has been demonstrated that the T-helper 2 and T-regulatory cell responses elicited by helminths can affect the ability of the host to control mycobacterial infection, it is still unclear whether helminth infections in fact affect tuberculosis disease. In this review article, current progress in the knowledge about the immunomodulation induced by helminths to diminish the protective immune responses to bacille Calmette-Guerin vaccination is reviewed, and the knowledge about the types of immune responses modulated by helminths and the consequences for tuberculosis are summarized. In addition, recent data supporting the significant reduction of both M. tuberculosis antigen-specific Toll-like receptor (TLR) 2 and TLR9 expression, and pro-inflammatory cytokine responses to TLR2 and TLR9 ligands in individuals with M. tuberculosis and helminth co-infection were discussed. This examination will allow to improve understanding of the immune responses to mycobacterial infection and also be of great relevance in combating human tuberculosis.
목차
Abstract
INTRODUCTION
IMMUNITY AGAINST TUBERCULOSIS
IMMUNOLOGY OF HELMINTH AND M. TUBERCULOSIS CO-INFECTION
IMMUNITY FOR HELMINTH INFECTIONS
IMMUNOLOGY OF HELMINTH AND OTHER MYCOBACTERIUM CO-INFECTIONS
CONCLUDING REMARKS
REFERENCES
참고문헌 (53)
참고문헌 신청
1. [보고서] - World Health Organization / 2008 / Global Tuberculosis Control-Surveillance, Planning, Financing. Geneva, Switzerland : 294 ~
2. [학술지(정기간행물)] - Gandhi NR / 2006 / Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa / Lancet 368 : 1575 ~ 1580
3. [학술지(정기간행물)] - Colditz GA / 1994 / Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature / JAMA 271 : 698 ~ 702
4. [학술지(정기간행물)] - Trunz BB / 2006 / Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: A meta-analysis and assessment of cost- effectiveness / Lancet 367 : 1173 ~ 1180
5. [학술지(정기간행물)] - Maizels RM / 2003 / Immune regulation by helminth parasites: Cellular and molecular mechanisms / Nat Rev Immunol 3 : 733 ~ 744
2. [학술지(정기간행물)] - Gandhi NR / 2006 / Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa / Lancet 368 : 1575 ~ 1580
3. [학술지(정기간행물)] - Colditz GA / 1994 / Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature / JAMA 271 : 698 ~ 702
4. [학술지(정기간행물)] - Trunz BB / 2006 / Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: A meta-analysis and assessment of cost- effectiveness / Lancet 367 : 1173 ~ 1180
5. [학술지(정기간행물)] - Maizels RM / 2003 / Immune regulation by helminth parasites: Cellular and molecular mechanisms / Nat Rev Immunol 3 : 733 ~ 744
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UCI(KEPA) : I410-ECN-0101-2014-510-002534749