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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 207 - 217 (11page)
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이 논문의 연구 히스토리 (7)
2006
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This study was conducted in order to investigate the effects of Artemisia capillaris (AC) extract on disorders of hepatic functions and lipid metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disrupter, using male rats (SD, five weeks old) for a period of three weeks. These 37 animals were divided into four groups. AC extract was added as 1.5% or 3% levels to basal diets, respectively. TCDD (40 ug/kg B.W) was administered by intraperitoneal injection into rats after a week from the beginning of the experiment. AC extract alleviated the increase of rat’s relative liver weights induced by TCDD. Thymuses of all rats treated with TCDD were apparently shrunken by approximately 80%. Levels of white blood cells (WBC), red blood cells, hemoglobin, and hematocrits were significantly increased by treatment with TCDD, however, WBC tended to decrease by AC extract diets. In hepatic function, the elevation of glutamic oxalacetic transaminase activities by TCDD treatment was diminished by AC extract diets. Serum HDL-cholesterol levels were significantly elevated by AC extract diets. The apparent increase of triglyceride levels of rat livers induced by TCDD was significantly suppressed in the AC extract diet groups. Hepatic cytosolic catalase activities significantly decreased by treatment with TCDD showed a recovering trend by AC extract diets. In histochemical observation, the fat droplets and apoptosis of hepatocytes treated with TCDD were markedly alleviated by AC extract diets. These results indicated that AC could exert recovering effects on some disorders of hepatic functions, lipids metabolism, and antioxidant activities resulting from TCDD treatment.
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Literature cited
참고문헌 (42)
참고문헌 신청
1. [학위논문] - Hwang SY / 1999 / Protective effects of Panax ginseng on TCDD-induced toxicity in male guinea pig / 박사 / Hannam University
2. [학술지(정기간행물)] - Shon YH / 2001 / Effect of chitosan oligosaccharides on dioxin-induced CYP1A1 activity and lipid peroxidation / J Chitin Chitosan 6 (3) : 107 ~ 110
3. [학위논문] - Park JB / 2004 / Protective effects of cricket extract YCY against hepatotoxicity induced by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in rats / 석사 / Daejeon University
4. [학술지(정기간행물)] - Hanson J / 1991 / Dioxin toxicity: new studies prompt debate, regulatory action / Chem Eng News 69 (32) : 7 ~ 14
5. [학술지(정기간행물)] - Jones G / 1974 / A morphological study of the liver lesion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats / J Pathol 112 (2) : 93 ~ 97
2. [학술지(정기간행물)] - Shon YH / 2001 / Effect of chitosan oligosaccharides on dioxin-induced CYP1A1 activity and lipid peroxidation / J Chitin Chitosan 6 (3) : 107 ~ 110
3. [학위논문] - Park JB / 2004 / Protective effects of cricket extract YCY against hepatotoxicity induced by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in rats / 석사 / Daejeon University
4. [학술지(정기간행물)] - Hanson J / 1991 / Dioxin toxicity: new studies prompt debate, regulatory action / Chem Eng News 69 (32) : 7 ~ 14
5. [학술지(정기간행물)] - Jones G / 1974 / A morphological study of the liver lesion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats / J Pathol 112 (2) : 93 ~ 97
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