Purpose: This study was conducted to investigate the level of sense of coherence (SOC) and stress of clinical practice and to identify the relationship of variables among nursing students. Methods: The data were collected from 205 nursing students using self-report questionnaire. Data were analyzed by frequencies, t-test, ANOVA, Pearson‘s correlation coefficients and Stepwise multiple regression using the SPSS program. Results: Stress of clinical practice negatively correlated with SOC. The significant predictors of stress of clinical practice were satisfaction on major and meaningfulness, manageability in SOC. The regression model explained 21.5% of stress of clinical practice. Conclusion: More efforts to improve satisfaction of their major and SOC, especially in meaningfulness and manageability, might decrease the stress of clinical practice.