지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The object of this study was to obtain acute information (single oral dose toxicity) of Taraxaci Herba (Dried total parts of Taraxacum platycarpum. H.Dahlstedt (Compositae)), has been traditionally used in Korean medicine for treating various inflammatory diseases. In order to observe the 50% lethal dose (LD 50), approximate lethal dosage (ALD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 ㎎/㎏ according to the recommendation of Korea Food and Drug Administration Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after single oral treatment of Taraxaci Herba aqueous extracts according to KFDA Guidelines with organ weights and histopathological observations of 12 types of principle organs. After single oral treatment of Taraxaci Herba aqueous extracts, we could not find any mortality and toxicological evidences up to 2,000 ㎎/㎏ treated group, the limited dosages in rodents at body and organ weights, clinical signs, gross and histopathological observations. Except for slight soft feces, which were detected in male mice treated with 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts at 1 day after end of treatment. The results obtained in this study suggest that the LD 50 and ALD of Taraxaci Herba aqueous extracts in both female and male mice after single oral treatment were considered as over 2,000 ㎎/㎏ because no mortalities were detected up to 2000 ㎎/㎏ that was the highest dose recommended by KFDA and OECD. However, it also observed that the possibility of digestive disorders, like diarrhea when administered over 2,000 ㎎/㎏ of Taraxaci Herba aqueous extracts in the present study, but these possibilities of digestive disorders can be disregard in clinical use because they ate transient in the highest dosages male only.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (41)
참고문헌 신청
1. [단행본] - 김인락 / 2007 / 本草學 / 圖書出版 永林社 : 243 ~ 245
2. [단행본] - 류종훈 / 2006 / 한방약리학 / 신일상사 : 225 ~ 227
3. [단행본] - 경희대학교 약학대학 / 2002 / 건강기능식품의 기능성평가 체계 구축에 대한 연구 / 식품의약품안전청
4. [학술지(정기간행물)] - 이미경 / 2009 / 황련과 단삼의 독성평가를 위한 성분분석 및 안정성 시험 / 생약학회지 40 (3) : 184 ~ 189
5. [학술지(정기간행물)] - 장인규 / 1985 / 죽력 (竹瀝)의 독성시험 및 약효학적 연구 / 대한한방내과학회지 2 : 83 ~ 101
2. [단행본] - 류종훈 / 2006 / 한방약리학 / 신일상사 : 225 ~ 227
3. [단행본] - 경희대학교 약학대학 / 2002 / 건강기능식품의 기능성평가 체계 구축에 대한 연구 / 식품의약품안전청
4. [학술지(정기간행물)] - 이미경 / 2009 / 황련과 단삼의 독성평가를 위한 성분분석 및 안정성 시험 / 생약학회지 40 (3) : 184 ~ 189
5. [학술지(정기간행물)] - 장인규 / 1985 / 죽력 (竹瀝)의 독성시험 및 약효학적 연구 / 대한한방내과학회지 2 : 83 ~ 101
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0