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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 344 - 347 (4page)
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초록· 키워드
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The S100A8 and S100A9 proteins play important roles in inflammatory diseases. The house dust mite acts as a major allergen that induces allergic diseases. We investigated the effect of the house dust mite on S100A8 and S100A9 protein expression in monocytes. We also examined the effect of CCL2, a powerful monocyte chemoattractant, on the expression of both proteins. Extract of Dermatophagoides pteronissinus (DP), recombinant Der p 1 and Der p 2, or CCL2 had no effect on S100A8 and S100A9 expression in human monocytic THP-1 cells. Monocytes were isolated from healthy donors and treated with DP, Der p 1, and Der p 2. S100A8 expression in monocytes increased after a 24 h stimulation with DP, Der p 1, and Der p 2, and CCL2 also increased S100A8 production. However, S100A9 expression in monocytes was not altered by DP, Der p 1, Der p 2, or CCL2. These results indicate that house dust mite and CCL2 may trigger an inflammatory response by altering S100A8 expression.
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REFERENCES
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Cui Y / 2013 / Structural biology of mite allergens / Mol Biol Rep 40 : 681 ~ 686
2. [학술지(정기간행물)] - Deshmane SL / 2009 / Monocyte chemoattractant protein-1 (MCP-1) / J Interferon Cytokine Res 29 : 313 ~ 326
3. [학술지(정기간행물)] - Endoh Y / 2009 / IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA / J Immunol 182 : 2258 ~ 2268
4. [학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
5. [학술지(정기간행물)] - Gavino AC / 2008 / Atopic dermatitis, patch testing, and house dust mites: a brief review / Dermatitis 19 : 121 ~ 128
2. [학술지(정기간행물)] - Deshmane SL / 2009 / Monocyte chemoattractant protein-1 (MCP-1) / J Interferon Cytokine Res 29 : 313 ~ 326
3. [학술지(정기간행물)] - Endoh Y / 2009 / IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA / J Immunol 182 : 2258 ~ 2268
4. [학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
5. [학술지(정기간행물)] - Gavino AC / 2008 / Atopic dermatitis, patch testing, and house dust mites: a brief review / Dermatitis 19 : 121 ~ 128
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