지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.3
- 발행연도
- 2014.9
- 수록면
- 129 - 135 (7page)
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The protective role of phloroglucinol against oxidative stress and stress-induced premature senescence (SIPS) was investigated in vitro and in cell culture. Phloroglucinol had strong and concentration-dependent radical scavenging effects against nitric oxide (NO), superoxide anions (O₂<SUP>?</SUP>), and hydroxyl radicals. In this study, free radical generators were used to induce oxidative stress in LLC-PK1 renal epithelial cells. Treatment with phloroglucinol attenuated the oxidative stress induced by peroxyl radicals, NO, O₂<SUP>?</SUP>, and peroxynitrite. Phloroglucinol also increased cell viability and decreased lipid peroxidation in a concentration-dependent manner. WI-38 human diploid fibroblast cells were used to investigate the protective effect of phloroglucinol against hydrogen peroxide (H₂O₂)-induced SIPS. Phloroglucinol treatment attenuated H₂O₂-induced SIPS by increasing cell viability and inhibited lipid peroxidation, suggesting that treatment with phloroglucinol should delay the aging process. The present study supports the promising role of phloroglucinol as an antioxidative agent against free radical-induced oxidative stress and SIPS.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Kovacic P / 2001 / Mechanisms of carcinogenesis:focus on oxidative stress and electron transfer / Curr Med Chem 8 : 773 ~ 796
2. [학술지(정기간행물)] - Valko M / 2001 / Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer? / Biochim Biophys Acta 1527 : 161 ~ 166
3. [학술지(정기간행물)] - Ridnour LA / 2005 / Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1 / Proc Natl Acad Sci USA 102 : 13147 ~ 13152
4. [학술지(정기간행물)] - Valko M / 2006 / Free radicals, metals and antioxidants in oxidative stressinduced cancer / Chem Biol Interact 160 : 1 ~ 40
5. [학술지(정기간행물)] - Dhalla NS / 2000 / Role of oxidative stress in cardiovascular diseases / J Hypertens 18 : 655 ~ 673
2. [학술지(정기간행물)] - Valko M / 2001 / Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer? / Biochim Biophys Acta 1527 : 161 ~ 166
3. [학술지(정기간행물)] - Ridnour LA / 2005 / Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1 / Proc Natl Acad Sci USA 102 : 13147 ~ 13152
4. [학술지(정기간행물)] - Valko M / 2006 / Free radicals, metals and antioxidants in oxidative stressinduced cancer / Chem Biol Interact 160 : 1 ~ 40
5. [학술지(정기간행물)] - Dhalla NS / 2000 / Role of oxidative stress in cardiovascular diseases / J Hypertens 18 : 655 ~ 673
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UCI(KEPA) : I410-ECN-0101-2015-510-002746327