지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.2
- 발행연도
- 2015.1
- 수록면
- 55 - 62 (8page)
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초록· 키워드
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Purpose: The anticancer property and cytoprotective role of selenium in chemotherapy have been reported. However, the combination effects of selenium on chemotherapy for advanced breast cancer have not yet been clearly defined. The purpose of this study was to investigate the combined effects of selenium on chemotherapy using docetaxel on breast cancer cell lines.
Methods: Under adherent culture conditions, two breast cancer cell lines, MDA-MB-231 and MCF-7, were treated with docetaxel at 500pM and selenium at 100nM, 1μM, or 10μM. Changes in cell growth, cell cycle duration, and degree of apoptosis after 72 hours in each treated group were evaluated.
Results: In the MDA-MB-231 cells, the combination therapy group (docetaxel at 500pM plus selenium at 10mM) showed a significantly decreased percentage of cell growth (15% vs. 28%; P = 0.004), a significantly increased percentage of late apoptosis (63% vs. 26%; P = 0.001), and an increased cell cycle arrest in the G2/M phase (P = 0.001) compared with the solitary docetaxel therapy group. Isobologram analysis demonstrated the synergistic effect of the combination therapy in the MDA-MB-231 cells. However, in the MCF-7 cells, no significant differences in the percentage of cell growth apoptosis, the percentage of apoptosis, and the pattern of cell cycle arrest were noted between the combination therapy groups and the solitary docetaxel therapy group.
Conclusion: Our in vitro study indicated that the combination of selenium with docetaxel inhibits cell proliferation through apoptosis and cell arrest in the G2/M phase in MDA-MB-231 breast cancer cells.
Methods: Under adherent culture conditions, two breast cancer cell lines, MDA-MB-231 and MCF-7, were treated with docetaxel at 500pM and selenium at 100nM, 1μM, or 10μM. Changes in cell growth, cell cycle duration, and degree of apoptosis after 72 hours in each treated group were evaluated.
Results: In the MDA-MB-231 cells, the combination therapy group (docetaxel at 500pM plus selenium at 10mM) showed a significantly decreased percentage of cell growth (15% vs. 28%; P = 0.004), a significantly increased percentage of late apoptosis (63% vs. 26%; P = 0.001), and an increased cell cycle arrest in the G2/M phase (P = 0.001) compared with the solitary docetaxel therapy group. Isobologram analysis demonstrated the synergistic effect of the combination therapy in the MDA-MB-231 cells. However, in the MCF-7 cells, no significant differences in the percentage of cell growth apoptosis, the percentage of apoptosis, and the pattern of cell cycle arrest were noted between the combination therapy groups and the solitary docetaxel therapy group.
Conclusion: Our in vitro study indicated that the combination of selenium with docetaxel inhibits cell proliferation through apoptosis and cell arrest in the G2/M phase in MDA-MB-231 breast cancer cells.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - 고범석 / 2012 / Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database / Journal of Breast Cancer 15 (4) : 393 ~ 400
2. [학술지(정기간행물)] - Leclere B. / 2013 / Trends in incidence of breast cancer among women under 40 in seven European countries : a GRELL cooperative study / Cancer Epidemiol 37 : 544 ~ 549
3. [학술지(정기간행물)] - Siegel R. / 2012 / Cancer statistics, 2012 / CA Cancer J Clin 62 : 10 ~ 29
4. [학술지(정기간행물)] - Yvon AM. / 1999 / Taxol suppresses dynamics of individual microtubules in living human tumor cells / Mol Biol Cell 10 : 947 ~ 959
5. [학술지(정기간행물)] - Kleeberg UR. / 2013 / Adjuvant therapy reduces the benefit of palliative treatment in disseminated breast cancer : own findings and review of the literature / Onkologie 36 : 348 ~ 356
2. [학술지(정기간행물)] - Leclere B. / 2013 / Trends in incidence of breast cancer among women under 40 in seven European countries : a GRELL cooperative study / Cancer Epidemiol 37 : 544 ~ 549
3. [학술지(정기간행물)] - Siegel R. / 2012 / Cancer statistics, 2012 / CA Cancer J Clin 62 : 10 ~ 29
4. [학술지(정기간행물)] - Yvon AM. / 1999 / Taxol suppresses dynamics of individual microtubules in living human tumor cells / Mol Biol Cell 10 : 947 ~ 959
5. [학술지(정기간행물)] - Kleeberg UR. / 2013 / Adjuvant therapy reduces the benefit of palliative treatment in disseminated breast cancer : own findings and review of the literature / Onkologie 36 : 348 ~ 356
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UCI(KEPA) : I410-ECN-0101-2016-514-001071605