지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.4
- 발행연도
- 2015.3
- 수록면
- 187 - 192 (6page)
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초록· 키워드
오류제보하기
Purpose: We evaluated the capability of the neutrophil to lymphocyte ratio (NLR) as a diagnostic tool to discriminate between poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) from well differentiated thyroid cancer (WDTC).
Methods: The NLR of 3,870 patients with benign and malignant thyroid tumors were analyzed. There were 436 benign, 3,364 papillary, 15 medullary, 34 follicular or hurthle type, 14 PDTC, and 7 ATC type neoplasms. Patients were divided into two groups: a high NLR group and a low NLR group.
Results: The NLR of all 3,870 patients was a normal distribution, and the median value was 1.57. Advanced stage cancer, such as T3 or T4 was high (30.4% vs. 26.5%, P = 0.027), and cancer-specific deaths were also high (1.2% vs. 0.4%, P = 0.018) in the high NLR group. The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group. The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC. None of the NLR of PDTC exceeded the cutoff value of 3.8.
Conclusion: NLR can play a relevant role as a discriminating tool and may be considered as a new diagnostic criterion in discriminating as well as in selecting therapeutic approaches to these aggressive forms of thyroid cancer.
Methods: The NLR of 3,870 patients with benign and malignant thyroid tumors were analyzed. There were 436 benign, 3,364 papillary, 15 medullary, 34 follicular or hurthle type, 14 PDTC, and 7 ATC type neoplasms. Patients were divided into two groups: a high NLR group and a low NLR group.
Results: The NLR of all 3,870 patients was a normal distribution, and the median value was 1.57. Advanced stage cancer, such as T3 or T4 was high (30.4% vs. 26.5%, P = 0.027), and cancer-specific deaths were also high (1.2% vs. 0.4%, P = 0.018) in the high NLR group. The proportion of PDTC (0.6% vs. 0.1%) and ATC (0.3% vs. 0.1%) was higher in the high NLR group. The NLR can discriminate between PTC, PDTC, and ATC (P = 0.035, P = 0.002, and P = 0.025, respectively), and the cutoff value was 3.8 between PDTC versus ATC. None of the NLR of PDTC exceeded the cutoff value of 3.8.
Conclusion: NLR can play a relevant role as a discriminating tool and may be considered as a new diagnostic criterion in discriminating as well as in selecting therapeutic approaches to these aggressive forms of thyroid cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Sobrinho-Simoes M. / 2002 / Poorly differentiated carcinomas of the thyroid gland : a review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors / Int J Surg Pathol 10 : 123 ~ 131
2. [학술지(정기간행물)] - Tallini G. / 2011 / Poorly differentiated thyroid carcinoma. Are we there yet? / Endocr Pathol 22 : 190 ~ 194
3. [학술지(정기간행물)] - Volante M. / 2004 / Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns : a clinicopathologic study of 183 patients / Cancer 100 : 950 ~ 957
4. [학술지(정기간행물)] - Carcangiu ML. / 1984 / Poorly differentiated ("insular") thyroid carcinoma. A reinterpretation of Langhans' "wuchernde Struma" / Am J Surg Pathol 8 : 655 ~ 668
5. [학술지(정기간행물)] - Blandino G. / 1999 / Mutant p53 gain of function : differential effects of different p53 mutants on resistance of cultured cells to chemotherapy / Oncogene 18 : 477 ~ 485
2. [학술지(정기간행물)] - Tallini G. / 2011 / Poorly differentiated thyroid carcinoma. Are we there yet? / Endocr Pathol 22 : 190 ~ 194
3. [학술지(정기간행물)] - Volante M. / 2004 / Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns : a clinicopathologic study of 183 patients / Cancer 100 : 950 ~ 957
4. [학술지(정기간행물)] - Carcangiu ML. / 1984 / Poorly differentiated ("insular") thyroid carcinoma. A reinterpretation of Langhans' "wuchernde Struma" / Am J Surg Pathol 8 : 655 ~ 668
5. [학술지(정기간행물)] - Blandino G. / 1999 / Mutant p53 gain of function : differential effects of different p53 mutants on resistance of cultured cells to chemotherapy / Oncogene 18 : 477 ~ 485
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UCI(KEPA) : I410-ECN-0101-2016-514-001306681