Low Fetal Weight is Directly Caused by Sequestration of Parasites and Indirectly by IL-17 and IL-10 Imbalance in the Placenta of Pregnant Mice with Malaria

Loeki Enggar Fitri; Teguh Wahju Sardjono; Zainabur Rahmah; Budi Siswanto; Kusworini Handono; Yoes Prijatna Dachlan

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자료유형: 학술저널

저자정보: Loeki Enggar Fitri (Universitas Brawijaya) Teguh Wahju Sardjono (Universitas Brawijaya) Zainabur Rahmah (Universitas Brawijaya) Budi Siswanto (Universitas Brawijaya) Kusworini Handono (Universitas Brawijaya) Yoes Prijatna Dachlan (Universitas Airlangga)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.2

발행연도: 2015.4

수록면: 189 - 196 (8page)

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The sequestration of infected erythrocytes in the placenta can activate the syncytiotrophoblast to release cytokines that affect the micro-environment and influence the delivery of nutrients and oxygen to fetus. The high level of IL-10 has been reported in the intervillous space and could prevent the pathological effects. There is still no data of Th17 involvement in the pathogenesis of placental malaria. This study was conducted to reveal the influence of placental IL-17 and IL-10 levels on fetal weights in malaria placenta. Seventeen pregnant BALB/C mice were divided into control (8 pregnant mice) and treatment group (9 pregnant mice infected by Plasmodium berghei). Placental specimens stained with hematoxylin and eosin were examined to determine the level of cytoadherence by counting the infected erythrocytes in the intervillous space of placenta. Levels of IL-17 and IL-10 in the placenta were measured using ELISA. All fetuses were weighed by analytical balance. Statistical analysis using Structural Equation Modeling showed that cytoadherence caused an increased level of placental IL-17 and a decreased level of placental IL-10. Cytoadherence also caused low fetal weight. The increased level of placental IL-17 caused low fetal weight, and interestingly low fetal weight was caused by a decrease of placental IL-10. It can be concluded that low fetal weight in placental malaria is directly caused by sequestration of the parasites and indirectly by the local imbalance of IL-17 and IL-10 levels.

#Plasmodium berghei #placental malaria #cytoadherence #IL-17 #IL-10 #low fetal weight

참고문헌 (32)

참고문헌 신청

Guyatt HL / 2004 / Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa / Clin Microbiol Rev 17:760~769

Kemenkes RI / 2012 / Bulletin of Malaria: epidemiology of Malaria in Indonesia / First Quarter :1~17

Mens PF / 2010 / Molecular interactions in the placenta during malaria infection / Eur J Obstet Gynecol Reprod Biol 152:126~132

Krishnegowda G / 2005 / Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI Activity / J Biol Chem 280:8606~8616

Nebl T / 2005 / Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors / Parasitology 130:S45~S62

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