지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 371 - 377 (7page)
이용수
초록· 키워드
오류제보하기
Trichomonas vaginalis induces proinflammation in cervicovaginal mucosal epithelium. To investigate the signaling pathways in TNF-α production in cervical mucosal epithelium after T. vaginalis infection, the phosphorylation of PI3K/AKT and MAPK pathways were evaluated in T. vaginalis-infected SiHa cells in the presence and absence of specific inhibitors. T. vaginalis increased TNF-α production in SiHa cells, in a parasite burden-dependent and incubation time-dependent manner. In T. vaginalis-infected SiHa cells, AKT, ERK1/2, p38 MAPK, and JNK were phosphorylated from 1 hr after infection; however, the phosphorylation patterns were different from each other. After pretreatment with inhibitors of the PI3K/AKT and MAPK pathways, TNF-α production was significantly decreased compared to the control; however, TNF-α reduction patterns were different depending on the type of PI3K/MAPK inhibitors. TNF-α production was reduced in a dose-dependent manner by treatment with wortmannin and PD98059, whereas it was increased by SP600125. These data suggested that PI3K/AKT and MAPK signaling pathways are important in regulation of TNF-α production in cervical mucosal epithelial SiHa cells. However, activation patterns of each pathway were different from the types of PI3K/MAPK pathways.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Johnston VJ / 2008 / Global epidemiology and control of Trichomonas vaginalis / Curr Opin Infect Dis 21 : 56 ~ 64
[학술지(정기간행물)] - Ryan CM / 2011 / Trichomonas vaginalis: current understanding of host-parasite interactions / Essays Biochem 51 : 161 ~ 175
[학술지(정기간행물)] - Van der Pol B / 2007 / Trichomonas vaginalis infection: the most prevalent nonviral sexually transmitted infection receives the least public health attention / Clin Infect Dis 44 : 23 ~ 25
[학술지(정기간행물)] - Coleman JS / 2013 / Trichomonas vaginalis vaginitis in obstetrics and gynecology practice: new concepts and controversies / Obstet Gynecol Surv 68 : 43 ~ 50
[학술지(정기간행물)] - Guenthner PC / 2005 / Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1 / Infect Immun 73 : 4155 ~ 4160
[학술지(정기간행물)] - Ryan CM / 2011 / Trichomonas vaginalis: current understanding of host-parasite interactions / Essays Biochem 51 : 161 ~ 175
[학술지(정기간행물)] - Van der Pol B / 2007 / Trichomonas vaginalis infection: the most prevalent nonviral sexually transmitted infection receives the least public health attention / Clin Infect Dis 44 : 23 ~ 25
[학술지(정기간행물)] - Coleman JS / 2013 / Trichomonas vaginalis vaginitis in obstetrics and gynecology practice: new concepts and controversies / Obstet Gynecol Surv 68 : 43 ~ 50
[학술지(정기간행물)] - Guenthner PC / 2005 / Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1 / Infect Immun 73 : 4155 ~ 4160
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Interaction between Trichomonas vaginalis and the Prostate Epithelium
Parasites, Hosts and Diseases
2017 .04
-
Transcriptomic analysis reveals M-MSCs improved therapeutic effects due to PI3K-Akt and MAPK signaling pathway in IC/BPS
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Prevalence of Trichomonas vaginalis in Women Visiting 2 Obstetrics and Gynecology Clinics in Daegu, South Korea
Parasites, Hosts and Diseases
2016 .02
-
Prevalence of Trichomoniasis by PCR in Women Attending Health Screening in Korea
Parasites, Hosts and Diseases
2016 .04
-
Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
Parasites, Hosts and Diseases
2023 .02
-
Influence of 120 kDa Pyruvate:Ferredoxin Oxidoreductase on Pathogenicity of Trichomonas vaginalis
Parasites, Hosts and Diseases
2016 .02
-
Loop-Mediated Isothermal Amplification Targeting Actin DNA of Trichomonas vaginalis
Parasites, Hosts and Diseases
2016 .06
-
Inflammatory Responses in a Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) Infected with Trichomonas vaginalis
Parasites, Hosts and Diseases
2016 .04
-
Activation of MAPK Is Required for ROS Generation and Exocytosis in HMC-1 Cells Induced by Trichomonas vaginalis-Derived Secretory Products
Parasites, Hosts and Diseases
2015 .10
-
Differential Protein Expressions in Virus-Infected and Uninfected Trichomonas vaginalis
Parasites, Hosts and Diseases
2017 .04
-
Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
Parasites, Hosts and Diseases
2021 .12
-
Propofol attenuates hydrogenperoxide- induced apoptosis in human umbilical vein endothelial cells via multiple signaling pathways
Korean Journal of Anesthesiology
2015 .01
-
Upregulation of TNF-α by Triglycerides is Mediated by MEK1 Activation in Jurkat T Cells
대한의생명과학회지
2018 .09
-
Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis
Parasites, Hosts and Diseases
2021 .06
-
Fenhexamid stimulated the cell viability and migration in an estrogen receptor-dependent and PI3K/AKT pathway in breast cancer cells
한국실험동물학회 학술발표대회 논문집
2019 .01
-
6-Shogaol suppresses oral cancer cell growth by Inhibiting AKT signaling pathway
한국실험동물학회 학술발표대회 논문집
2022 .01
-
IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
Parasites, Hosts and Diseases
2017 .12
-
Imatinib inhibits oral squamous cell carcinoma by suppressing the PI3K/AKT/mTOR signaling pathway
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Excretory-Secretory Products of Trichomonas vaginalis Cause Apoptosis in Mouse Sperm in Vitro
Parasites, Hosts and Diseases
2022 .10
-
Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo
한국실험동물학회 학술발표대회 논문집
2019 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
송이버섯 추출액의 항균력 확인과 저염젓갈 생산에 적용 가능성
김진성
,
박재범
,
장승원
외 4명
KSBB Journal
2015
.10
MALDI-MS 기반 당단백질 당쇄의 정량분석 기술 개발 연구 동향
김경진
,
김윤우
,
황철환
외 3명
KSBB Journal
2015
.10
LPS로 유도된 RAW264.7 Cell과 마우스모델에 대한 잘피 에탄올 추출물의 항염증 효과
김민지
,
배난영
,
김꽃봉우리
외 4명
KSBB Journal
2015
.08
Production of Liquiritigenin with Cell-based Biotransformation and Its Anti-Aging Activity
Hye Jin Hwang
,
Sang Chul Jeong
,
Jong Pil Pa
외 1명
KSBB Journal
2015
.08
Low Fetal Weight is Directly Caused by Sequestration of Parasites and Indirectly by IL-17 and IL-10 Imbalance in the Placenta of Pregnant Mice with Malaria
Loeki Engga
,
Fit
,
i
외 9명
Parasites, Hosts and Diseases
2015
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-001839404