지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 547 - 556 (10page)
이용수
초록· 키워드
오류제보하기
Our objective was to investigate whether inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation of prostate cancer (PCa) cells in vitro and in vivo mouse experiments. The production of CXCL1 and CCL2 increased when cells of the mouse PCa cells (TRAMP-C2 cell line) were infected with live T. vaginalis. T. vaginalis-conditioned medium (TCM) prepared from co-culture of PCa cells and T. vaginalis increased PCa cells migration, proliferation and invasion. The cytokine receptors (CXCR2, CCR2, gp130) were expressed higher on the PCa cells treated with TCM. Pretreatment of PCa cells with antibodies to these cytokine receptors significantly reduced the proliferation, mobility and invasiveness of PCa cells, indicating that TCM has its effect through cytokine-cytokine receptor signaling. In C57BL/6 mice, the prostates injected with T. vaginalis mixed PCa cells were larger than those injected with PCa cells alone after 4 weeks. Expression of epithelial-mesenchymal transition markers and cyclin D1 in the prostate tissue injected with T. vaginalis mixed PCa cells increased than those of PCa cells alone. Collectively, it was suggested that inflammatory reactions by T. vaginalis-stimulated PCa cells increase the proliferation and invasion of PCa cells through cytokine-cytokine receptor signaling pathways.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (48)
참고문헌 신청
World Health Organization / Report on Global Sexually Transmitted Infection Surveillance
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Škerka V / 200 / Aetiology of chronic prostatitis / Int J Antimicrob Agents 19:471~474
Jong Jin Lee / 2012 / PCR for Diagnosis of Male Trichomonas vaginalis Infection with Chronic Prostatitis and Urethritis / The Korean Journal of Parasitology 50(2):157~159
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
Menezes CB / 2016 / Trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide? / Microb Cell 3:404~419
Škerka V / 200 / Aetiology of chronic prostatitis / Int J Antimicrob Agents 19:471~474
Jong Jin Lee / 2012 / PCR for Diagnosis of Male Trichomonas vaginalis Infection with Chronic Prostatitis and Urethritis / The Korean Journal of Parasitology 50(2):157~159
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
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UCI(KEPA) : I410-ECN-0101-2022-513-001354096