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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 256 - 266 (11page)
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초록· 키워드
오류제보하기
Decreasing costs of genetic testing and interest in disease inheritance has changed the landscape of cancer prediction in prostate cancer (PCa), and guidelines now include genetic testing for high-risk groups. Familial and hereditary PCa comprises approximately 20% and 5% of all PCa, respectively. Multifaceted disorders like PCa are caused by a combinatory effect of rare genes of high penetrance and smaller genetic variants of relatively lower effect size. Polygenic risk score (PRS) is a novel tool utilizing PCa-associated single nucleotide polymorphisms (SNPs) identified from genome-wide association study (GWAS) to generate an additive estimate of an individual's lifetime genetic risk for cancer. However, most PRS are developed based on GWAS collected from mainly European populations and do not address ethnic differences in PCa genetics. This review highlights the attempts to generate a PRS tailored to Asian males including data from Korea, China, and Japan, and discuss the clinical implications for prediction of early onset and aggressive PCa.
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참고문헌 (66)
참고문헌 신청
Rawla P / 2019 / Epidemiology of prostate cancer / World J Oncol 10:63~89
Kimura T / 2012 / East meets West : ethnic differences in prostate cancer epidemiology between East Asians and Caucasians / Chin J Cancer 31:421~429
Kimura T / 2018 / Epidemiology of prostate cancer in Asian countries / Int J Urol 25:524~531
de Bono J / 2020 / Olaparib for metastatic castration-resistant prostate cancer / N Engl J Med 382:2091~2102
Clarke N / 2018 / Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer : a randomised, double-blind, placebo-controlled, phase 2 trial / Lancet Oncol 19:975~986
Kimura T / 2012 / East meets West : ethnic differences in prostate cancer epidemiology between East Asians and Caucasians / Chin J Cancer 31:421~429
Kimura T / 2018 / Epidemiology of prostate cancer in Asian countries / Int J Urol 25:524~531
de Bono J / 2020 / Olaparib for metastatic castration-resistant prostate cancer / N Engl J Med 382:2091~2102
Clarke N / 2018 / Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer : a randomised, double-blind, placebo-controlled, phase 2 trial / Lancet Oncol 19:975~986
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