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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1992.6
- 수록면
- 69 - 76 (8page)
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To evaluate in vitro anti herpetic efficacy of nucleoside analogues and precursor (base) analogues, Vero cells were infected with three different strains of HSV-1 and 2 of HSV-1 and 2 of HSV-2 and treated with the compounds. The antiviral activity was evaluated by virus-induced cytopathic effect(CPE) inhibition assay. Anti-CMV activity was measured by CPE inhibition assay and anti-VZV by plaque reduction assay. HEL 299 cells were used for the replication of CMV and VZV. VZV showed generally the highest sensitivity against tested compounds followed by HSV and CMV. There was no significant difference between anti-HSV-1 and anti HSV 2 activity of tested compounds except BVdUrd and TFT. But differences among strains of the same virus were rather observed. All compounds licensed for the clinical treatment, ACV, Ara A, IdUrd, TFT, GCV and PFA, showed in vitro efficacy against their target viruses. Cytostatic and cytocidal effects of the compounds were also measured by MTT assay in Vero cell cultures. The former were more significant than the latter.
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