지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 26 - 35 (10page)
이용수
초록· 키워드
오류제보하기
Vibrio vulnificus causes fatal infections in susceptible individuals. Group 1 capsular polysaccharide (CPS) operon is responsible for CPS expression, which plays an essential role in the pathogenesis of this pathogen. Cyclic AMP (cAMP) and cAMP receptor protein (Crp) complex, which responds to glucose availability and functions as a global regulator, has been known to affect CPS production in this pathogen. This study was undertaken to experimentally verify whether cAMP-Crp directly or indirectly affects CPS production. A mutation in cyaA encoding adenylate cyclase, which is required for cAMP biosynthesis, inhibited V. vulnificus growth and changed opaque colonies to translucent colonies, and these changes were recovered by complementing cyaA or by adding exogenous cAMP. A mutation in crp encoding Crp also inhibited V. vulnificus growth and changed opaque colonies to translucent colonies, and these changes were recovered by complementing crp. Moreover, the crp or cyaA mutation decreased the susceptibility of V. vulnificus against NaOCl. The crp mutation reduced the transcription levels of group 1 CPS operon on a per cell basis. Glucose addition in the absence of Crp stimulated V. vulnificus growth, changed translucent colonies to opaque colonies, and increased the transcription levels of group 1 CPS operon. These results indicate that cAMP or Crp is indirectly involved in optimal CPS production by positively affecting metabolism or V. vulnificus growth rather than by directly controlling the expression of group 1 CPS operon.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Jones MK / 2009 / Vibrio vulnificus: disease and pathogenesis / Infect Immun 77 : 1723 ~ 1733
2. [학술지(정기간행물)] - Kim YR / 2005 / Essential role of an adenylate cyclase in regulating Vibrio vulnificus virulence / FEMS Microbiol Lett 243 : 497 ~ 503
3. [학술지(정기간행물)] - Choi MH / 2006 / Effect of the crp mutation on the utilization of transferrin-bound iron by Vibrio vulnificus / FEMS Microbiol Lett 257 : 285 ~ 292
4. [학술지(정기간행물)] - Kim YR / 2013 / A dual regulatory role of cyclic adenosine monophosphate receptor protein in various virulence traits of Vibrio vulnificus / Microbiol Immunol 57 : 273 ~ 280
5. [학술지(정기간행물)] - LEE, JEONG HYUN / 2007 / Identification and Functional Analysis of Vibrio vulnificus SmcR, a Novel Global Regulator / Journal of Microbiology and Biotechnology 17 (2) : 325 ~ 334
2. [학술지(정기간행물)] - Kim YR / 2005 / Essential role of an adenylate cyclase in regulating Vibrio vulnificus virulence / FEMS Microbiol Lett 243 : 497 ~ 503
3. [학술지(정기간행물)] - Choi MH / 2006 / Effect of the crp mutation on the utilization of transferrin-bound iron by Vibrio vulnificus / FEMS Microbiol Lett 257 : 285 ~ 292
4. [학술지(정기간행물)] - Kim YR / 2013 / A dual regulatory role of cyclic adenosine monophosphate receptor protein in various virulence traits of Vibrio vulnificus / Microbiol Immunol 57 : 273 ~ 280
5. [학술지(정기간행물)] - LEE, JEONG HYUN / 2007 / Identification and Functional Analysis of Vibrio vulnificus SmcR, a Novel Global Regulator / Journal of Microbiology and Biotechnology 17 (2) : 325 ~ 334
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