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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.12
- 수록면
- 247 - 251 (5page)
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초록· 키워드
오류제보하기
Natural killer (NK) cells are CD3 (-) CD14 (-) CD56 (+) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. Methods: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. Results: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. Conclusion: These data suggest CRH can inhibit NK cell migration to target cells.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
, 2005 , subset resides lymph nodes and differentiates into CD56bright natural killer cells 22 : 295 ~ 304
, 2005 , NK cells in innate immunity 17 : 29 ~ 35
, 2002 , Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 20 : 323 ~ 370
, 2003 , Proline-rich tyrosine kinase 2 and Rac activation by chemokine and intergrin receptors controls NK cell transendothelial migration 170 (l) : 3065 ~ 3073
, 2004 , Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interacton with endothelial cells 34 : 1333 ~ 1341
, 2005 , NK cells in innate immunity 17 : 29 ~ 35
, 2002 , Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 20 : 323 ~ 370
, 2003 , Proline-rich tyrosine kinase 2 and Rac activation by chemokine and intergrin receptors controls NK cell transendothelial migration 170 (l) : 3065 ~ 3073
, 2004 , Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interacton with endothelial cells 34 : 1333 ~ 1341
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Corticotropin-Releasing Hormone (CRH)에 의한 인간 위암 세포(MKN-28)의 Migration 증가
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생쥐 미세아교세포(BV2)에서 Corticotropin-releasing Hormone (CRH)에 의한 Nitric Oxide (NO) 생성의 증가
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Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium
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Journal of genetic medicine
2007 .01
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Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy
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2018 .08
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NK Cell-Based Immunotherapies in Cancer
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2020 .04
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Expansion and Activation of Natural Killer Cells for Cancer Immunotherapy
Annals of Laboratory Medicine
2009 .01
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Signaling for Synergistic Activation of Natural Killer Cells
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2012 .12
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H2-M3의 세포 표면 발현이 NK 세포의 활성에 미치는 영향 분석
약학회지
2009 .01
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A novel kit for the analysis of NK cell activity using whole blood : Measurement of NK cell activity in disease model mice
한국실험동물학회 학술발표대회 논문집
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Inflammatory Mediators Modulate NK Cell-stimulating Activity of Dendritic Cells by Inducing Development of Polarized Effector Function
Immune Network
2007 .09
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말초혈액 자연살해세포가 증가된 반복유산 환자의 탈락막 자연살해세포의 발현
대한생식의학회지
2009 .01
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Expression of Decidual Natural Killer (NK) Cells in Women of Recurrent Spontaneous Abortion with Increased Peripheral NK Cells
대한생식의학회 학술대회
2007 .01
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The Correlation between NK Cell and Liver Function in Patients with Primary Hepatocellular Carcinoma
Gut and Liver
2014 .01
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말초혈액 내 NK cell 측정을 통한 암환자의 종양 면역 기능 평가 가능성 고찰
논문집 : 대전대학교 한의학연구소. 한의학편
2012 .01
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Enhanced Anti-Cancer Effect of Snake Venom Activated NK Cells on Lung Cancer Cells by Inactivation of NF-κB
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
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Comparison of FcRγ-Deficient and CD57+ Natural Killer Cells Between Cord Blood and Adult Blood in the Cytomegalovirus-Endemic Korean Population
Annals of Laboratory Medicine
2015 .01
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Post-transcriptional Regulation of NK Cell Activation
Immune Network
2009 .08
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Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity
Cancer Research and Treatment
2017 .01
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Cytotoxicity of natural killer cells co-cultured with γ-irradiatedor mitomycin C-treated feeder cells
예방수의학회지
2020 .01
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