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- 학술저널
- 저자정보
- 발행연도
- 2020.4
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- 42 - 68 (27page)
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초록· 키워드
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With the development of technologies that can transform immune cells into therapeutic modalities, immunotherapy has remarkably changed the current paradigm of cancer treatment in recent years. NK cells are components of the innate immune system that act as key regulators and exhibit a potent tumor cytolytic function. Unlike T cells, NK cells exhibit tumor cytotoxicity by recognizing non-self, without deliberate immunization or activation. Currently, researchers have developed various approaches to improve the number and anti-tumor function of NK cells. These approaches include the use of cytokines and Abs to stimulate the efficacy of NK cell function, adoptive transfer of autologous or allogeneic ex vivo expanded NK cells, establishment of homogeneous NK cell lines using the NK cells of patients with cancer or healthy donors, derivation of NK cells from induced pluripotent stem cells (iPSCs), and modification of NK cells with cutting-edge genetic engineering technologies to generate chimeric Ag receptor (CAR)-NK cells. Such NK cell-based immunotherapies are currently reported as being promising anti-tumor strategies that have shown enhanced functional specificity in several clinical trials investigating malignant tumors. Here, we summarize the recent advances in NK cell-based cancer immunotherapies that have focused on providing improved function through the use of the latest genetic engineering technologies. We also discuss the different types of NK cells developed for cancer immunotherapy and present the clinical trials being conducted to test their safety and efficacy.
목차
ABSTRACT
INTRODUCTION
CURRENT STATUS OF CANCER IMMUNOTHERAPY
NK CELL THERAPY: AN ALTERNATIVE TO CAR-T CELL THERAPY
LIMITATIONS OF CAR-T CELL THERAPY
AUTOLOGOUS AND ALLOGENEIC NK CELL THERAPY
NK CELL LINES
HUMAN IPSC-DERIVED NK CELLS
CAR-NK CELLS
IMMUNE CHECKPOINT THERAPY IN COMBINATION WITH NK CELLS
TUMOR MICROENVIRONMENT AND NK CELLS
CONCLUSION
REFERENCES
참고문헌 (133)
참고문헌 신청
Cheng M / 2013 / NK cell-based immunotherapy for malignant diseases / Cell Mol Immunol 10:230~252
Morvan MG / 2016 / NK cells and cancer : you can teach innate cells new tricks / Nat Rev Cancer 16:7~19
Long EO / 2013 / Controlling natural killer cell responses : integration of signals for activation and inhibition / Annu Rev Immunol 31:227~258
Berry R / 2013 / Targeting of a natural killer cell receptor family by a viral immunoevasin / Nat Immunol 14:699~705
Voskoboinik I / 2006 / Perforin-mediated target-cell death and immune homeostasis / Nat Rev Immunol 6:940~952
Morvan MG / 2016 / NK cells and cancer : you can teach innate cells new tricks / Nat Rev Cancer 16:7~19
Long EO / 2013 / Controlling natural killer cell responses : integration of signals for activation and inhibition / Annu Rev Immunol 31:227~258
Berry R / 2013 / Targeting of a natural killer cell receptor family by a viral immunoevasin / Nat Immunol 14:699~705
Voskoboinik I / 2006 / Perforin-mediated target-cell death and immune homeostasis / Nat Rev Immunol 6:940~952
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UCI(KEPA) : I410-ECN-0101-2020-517-000894455