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논문 기본 정보

자료유형
학술저널
저자정보
Hyunjae Shin (Seoul National University College of Medicine) Ha Seok Lee (Korea Advanced Institute of Science and Technology (KAIST)) Ji Yun Noh (Korea University Guro Hospital) June-Young Koh (Korea Advanced Institute of Science and Technology) So-Young Kim (Korea Advanced Institute of Science and Technology) Jeayeon Park (Seoul National University College of Medicine) Sung Won Chung (Seoul National University College of Medicine) Moon Haeng Hur (Seoul National University College of Medicine) Min Kyung Park (Seoul National University College of Medicine) Yun Bin Lee (Seoul National University College of Medicine) Yoon Jun Kim (Seoul National University College of Medicine) Jung-Hwan Yoon (Seoul National University College of Medicine) Jae-Hoon Ko (Sungkyunkwan UniversitySchool of Medicine) Kyong Ran Peck (Sungkyunkwan University School of Medicine) Joon Young Song (Korea University College of Medicine) Eui-Cheol Shin (Korea Advanced Institute of Science and Technology (KAIST)) Jeong-Hoon Lee (Seoul National University College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.23 No.5
발행연도
2023.10
수록면
42 - 56 (15page)

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초록· 키워드

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Coronavirus disease 2019 (COVID-19) vaccination may non-specifically alter the host immune system. This study aimed to evaluate the effect of COVID-19 vaccination on hepatitis B surface Ag (HBsAg) titer and host immunity in chronic hepatitis B (CHB) patients. Consecutive 2,797 CHB patients who had serial HBsAg measurements during antiviral treatment were included in this study. Changes in the HBsAg levels after COVID-19 vaccination were analyzed. The dynamics of NK cells following COVID-19 vaccination were also examined using serial blood samples collected prospectively from 25 healthy volunteers. Vaccinated CHB patients (n=2,329) had significantly lower HBsAg levels 1–30 days post-vaccination compared to baseline (median, −21.4 IU/ml from baseline), but the levels reverted to baseline by 91–180 days (median, −3.8 IU/ml). The velocity of the HBsAg decline was transiently accelerated within 30 days after vaccination (median velocity: −0.06, −0.39, and −0.04 log10 IU/ml/year in pre-vaccination period, days 1–30, and days 31–90, respectively). In contrast, unvaccinated patients (n=468) had no change in HBsAg levels. Flow cytometric analysis showed that the frequency of NK cells expressing NKG2A, an NK inhibitory receptor, significantly decreased within 7 days after the first dose of COVID-19 vaccine (median, −13.1% from baseline; p<0.001). The decrease in the frequency of NKG2A<SUP>+</SUP> NK cells was observed in the CD56<SUP>dim</SUP>CD16<SUP>+</SUP> NK cell population regardless of type of COVID-19 vaccine. COVID-19 vaccination leads to a rapid, transient decline in HBsAg titer and a decrease in the frequency of NKG2A<SUP>+</SUP> NK cells.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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