지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 554 - 562 (9page)
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초록· 키워드
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Purpose: Several studies have reported relationships among physical activity, healthy metabolic status, and increased naturalkiller (NK) cell activity. However, large-scale data thereon are lacking. Thus, the present study aimed to assess NK cell activity accordingto physical activity and metabolic status. Materials and Methods: A cross-sectional study was performed on 12014 asymptomatic examinees. Using a patented stimulatorycytokine, NK cell activity was quantitated by the amount of interferon-γ secreted into the plasma by NK cells. Physical activity levelswere assessed using the validated Korean version of the International Physical Activity Questionnaire Short Form. Results: The physically inactive group showed lower NK cell activity than the minimally active group (median, 1461 vs. 1592 pg/mL,p<0.001) and health-enhancing physically active group (median, 1461 vs. 1712 pg/mL, p=0.001). Compared to women with abody mass index (BMI) of 18.5−27.5 kg/m2, those with a BMI <18.5 kg/m2 had significantly lower NK cell activity (1356 vs. 1024 g/mL,p<0.001), and those with a BMI ≥27.5 kg/m2 tended to have lower NK cell activity (1356 vs. 1119 g/mL, p=0.070). Subjects withhigh hemoglobin A1c levels and low high-density lipoprotein cholesterol levels, as well as men with high blood pressure andwomen with high triglyceride levels, exhibited lower NK cell activity. Moreover, physical inactivity and metabolic abnormalitieswere independently associated with low NK cell activity, even after adjusting for confounders. Conclusion: Physical inactivity and metabolic abnormalities are associated with reduced NK cell activity. Immune systems maybecome altered depending on physical activity and metabolic status.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Bryceson YT / 2011 / Molecular mechanisms of natural killer cell activation / J Innate Immun 3:216~226
Imai K / 2000 / Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population / Lancet 356:1795~1799
Jobin G / 2017 / Association between natural killer cell activity and colorectal cancer in high-risk subjects undergoing colonoscopy / Gastroenterology 153:980~987
Lee J / 2017 / Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer / Oncotarget 8:70431~70440
Barkin J / 2017 / Association between natural killer cell activity and prostate cancer: a pilot study / Can J Urol 24:8708~8713
Imai K / 2000 / Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population / Lancet 356:1795~1799
Jobin G / 2017 / Association between natural killer cell activity and colorectal cancer in high-risk subjects undergoing colonoscopy / Gastroenterology 153:980~987
Lee J / 2017 / Natural killer cell activity for IFN-gamma production as a supportive diagnostic marker for gastric cancer / Oncotarget 8:70431~70440
Barkin J / 2017 / Association between natural killer cell activity and prostate cancer: a pilot study / Can J Urol 24:8708~8713
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