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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 67 - 75 (9page)
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Cytotoxic function of killer cells is inhibited by specific recognition of class I MHC molecules on target cells by inhibitory killer Ig-like receptors (KIR) expressed on NK cells and some cytotoxic T cells. The inhibitory effect of KIR is accomplished by recruitment of SH2-containing protein tyrosine phosphatase (SHP) to the phosphotyrosine residues in the cytoplasmic tail. Methods: By in vitro coprecipitation experiments and transfection analysis, we investigated the association of KIR with an adaptor protein Shc in Jurkat T cells. Results: The cytoplasmic tail of KIR appeared to associate with an adaptor protein Shc in Jurkat T celilysates. Similar in vitro experiments showed that phosphorylated KIR cytoplasmic tail bound SHP-1 and Shc in Jurkat T cell lysates. The association of KIR with Shc was further confirmed by transfection analysis in 293T cells. Interestingly, however, Shc appeared to be replaced by SHP-2 upon engagement of KIR in 293T cells. Conclusion: Our data indicate that KIR associate with an adaptor protein Shc in Jurkat T cells, and suggest that KIR might have an additional role which is mediated by this adaptor protein.
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참고문헌 (57)
참고문헌 신청
[학술지(정기간행물)] - / 2004 / Killer Immunoglobulin-like receptors 16 : 626 ~ 633
[학술지(정기간행물)] - / 1997 / Major histocompatibility complex class-I specific receptors on human natural killer and T lymphocytes 155 : 105 ~ 117
[학술지(정기간행물)] - / 1997 / NK cells 6 : 371 ~ 378
[학술지(정기간행물)] - / 1996 / Inhibitory MHC class I receptors on NK cells and T cells 17 : 86 ~ 91
[학술지(정기간행물)] - / 1995 / Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells 92 : 3536 ~ 3540
[학술지(정기간행물)] - / 1997 / Major histocompatibility complex class-I specific receptors on human natural killer and T lymphocytes 155 : 105 ~ 117
[학술지(정기간행물)] - / 1997 / NK cells 6 : 371 ~ 378
[학술지(정기간행물)] - / 1996 / Inhibitory MHC class I receptors on NK cells and T cells 17 : 86 ~ 91
[학술지(정기간행물)] - / 1995 / Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells 92 : 3536 ~ 3540
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