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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 107 - 123 (17page)
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It has now been well documented in a variety of models that T regulatory T cells (Treg cells) play a pivotal role in the maintenance of self-tolerance, T cell homeostasis, tumor, allergy, autoimmunity, allograft transplantation and control of microbial infection. Recently, Treg cell are isolated and can be expanded in vitro and in vivo, and their role is the subject of intensive investigation, particularly on the possible Treg cell therapy for various immune-mediated diseases. A growing body of evidence has demonstrated that Treg cells can prevent or even cure a wide range of diseases, including tumor, allergic and autoimmune diseases, transplant rejection, graft-versus-host disease. Currently, a large body of data in the literature has been emerging and provided evidence that clear understanding of Treg cell work will present definite opportunities for successful Treg cell immunotherapy for the treatment of a broad spectrum of diseases. In this Review, I briefly discuss the biology of Treg cells, and summarize efforts to exploit Treg cell therapy for autoimmune diseases. This article also explores recent observations on pharmaceutical agents that abrogate or enhance the function of Treg cells for manipulation of Treg cells for therapeutic purpose.
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참고문헌 (156)
참고문헌 신청
1. [학술지(정기간행물)] - Gershon RK / 1972 / Suppressor T cells / J Immunol 108 : 586 ~ 590
2. [학술지(정기간행물)] - Gershon RK / 1971 / Infectious immunological tolerance / Immunology 21 : 903 ~ 914
3. [학술지(정기간행물)] - Ha TY / 1973 / Role of the thymus in tolerance .X. “Suppressor” activity of antigen-stimulated rat thymocytes transferred to normal recipients / J Immunol 110 : 1290 ~ 1299
4. [학술지(정기간행물)] - Ha TY / 1974 / Thymic suppressor cell. I. Separation of subpopulation with suppressor activity / J Exp Med 139 : 13 ~ 23
5. [학술지(정기간행물)] - Ha TY / 1974 / The thymic suppressor cell. II. Metabolic requirement of suppressor activity / Immunol Commun 3 : 351 ~ 359
2. [학술지(정기간행물)] - Gershon RK / 1971 / Infectious immunological tolerance / Immunology 21 : 903 ~ 914
3. [학술지(정기간행물)] - Ha TY / 1973 / Role of the thymus in tolerance .X. “Suppressor” activity of antigen-stimulated rat thymocytes transferred to normal recipients / J Immunol 110 : 1290 ~ 1299
4. [학술지(정기간행물)] - Ha TY / 1974 / Thymic suppressor cell. I. Separation of subpopulation with suppressor activity / J Exp Med 139 : 13 ~ 23
5. [학술지(정기간행물)] - Ha TY / 1974 / The thymic suppressor cell. II. Metabolic requirement of suppressor activity / Immunol Commun 3 : 351 ~ 359
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