지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 16 - 26 (11page)
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초록· 키워드
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The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity against vaginal pathogens in the lower tract and establish immune tolerance for sperm and an embryo/fetus in the upper tract. The immune system is significantly influenced by sex steroid hormones, although leukocytes in the reproductive tract lack receptors for estrogen and progesterone. The leukocytes in the reproductive tract are distributed in either an aggregated or a dispersed form in the epithelial layer, lamina propria, and stroma. Even though immune cells are differentially distributed in each organ of the reproductive tract, the predominant immune cells are T cells, macrophages/dendritic cells, natural killer (NK) cells, neutrophils, and mast cells. B cells are rare in the female reproductive tract. NK cells in the endometrium significantly expand in the late secretory phase and further increase their number during early pregnancy. It is evident that NK cells and regulatory T (Treg) cells are extremely important in decidual angiogenesis, trophoblast migration, and immune tolerance during pregnancy. Dysregulation of endometrial/decidual immune cells is strongly related to infertility, miscarriage, and other obstetric complications. Understanding the immune system of the female reproductive tract will significantly contribute to women’s health and to success in pregnancy.
목차
INTRODUCTION
IMMUNE CELL DISTRIBUTION IN THE FEMALE REPRODUCTIVE TRACT
FLUCTUATION OF IMMUNE CELLS IN THE FEMALE REPRODUCTIVE TRACT DURING THE MENSTRUAL CYCLE
DECIDUAL IMMUNE CELLS DURING PREGNANCY
IMMUNE CELLS IN THE REPRODUCTIVE TRACT OF POSTMENOPAUSAL WOMEN
CLINICAL SIGNIFICANCE OF IMMUNE CELLS IN THE FEMALE REPRODUCTIVE TRACT
DISCUSSION
REFERENCES
참고문헌 (52)
참고문헌 신청
1. [학술지(정기간행물)] - Trifonova, R. T / 2014 / Distribution of immune cells in the human cervix and implications for HIV transmission / Am. J. Reprod. Immunol 71 : 252 ~ 264
2. [학술지(정기간행물)] - Lee, S, J. / 2010 / Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women / J. Immunol 185 : 756 ~ 762
3. [학술지(정기간행물)] - Wira, C. R / 2014 / Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens / Am. J. Reprod. Immunol 72 : 236 ~ 258
4. [학술지(정기간행물)] - Givan, A. L / 1997 / Flow cytometric analysis of leukocytes in the human female reproductive tract:comparison of fallopian tube, uterus, cervix, and vagina / Am. J. Reprod. Immunol 38 : 350 ~ 359
5. [학술지(정기간행물)] - Johansson, E. L. / 1999 / Distribution of lymphocytes and adhesion molecules in human cervix and vagina / Immunology 96 : 272 ~ 277
2. [학술지(정기간행물)] - Lee, S, J. / 2010 / Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women / J. Immunol 185 : 756 ~ 762
3. [학술지(정기간행물)] - Wira, C. R / 2014 / Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens / Am. J. Reprod. Immunol 72 : 236 ~ 258
4. [학술지(정기간행물)] - Givan, A. L / 1997 / Flow cytometric analysis of leukocytes in the human female reproductive tract:comparison of fallopian tube, uterus, cervix, and vagina / Am. J. Reprod. Immunol 38 : 350 ~ 359
5. [학술지(정기간행물)] - Johansson, E. L. / 1999 / Distribution of lymphocytes and adhesion molecules in human cervix and vagina / Immunology 96 : 272 ~ 277
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UCI(KEPA) : I410-ECN-0101-2016-511-001754537