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논문 기본 정보

자료유형
학술저널
저자정보
Sae-Hae Kim (Jeonbuk National University) Yong-Suk Jang (Jeonbuk National University)
저널정보
대한면역학회 Immune Network Immune Network Vol.20 No.6
발행연도
2020.12
수록면
1 - 19 (19page)

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초록· 키워드

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The human body is continuously threatened by pathogens, and the immune system must maintain a balance between fighting infection and becoming over-activated. Mucosal surfaces cover several anatomically diverse organs throughout the body, such as the respiratory and gastrointestinal tracts, and are directly exposed to the external environment. Various pathogens invade the body through mucosal surfaces, making the mucosa the frontline of immune defense. The immune systems of various mucosal tissues display distinctive features that reflect the tissues" anatomical and functional characteristics. This review discusses the cellular components that constitute the respiratory and gastrointestinal tracts; in particular, it highlights the complex interactions between epithelial and immune cells to induce Ag-specific immune responses in the lung and gut. This information on mucosal immunity may facilitate understanding of the defense mechanisms against infectious agents that invade mucosal surfaces, such as severe acute respiratory syndrome coronavirus 2, and provide insight into effective vaccine development.

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ABSTRACT
INTRODUCTION
CELLULAR COMPONENTS OF THE RESPIRATORY AND GASTROINTESTINAL TRACTS
INDUCTION AND REGULATION OF MUCOSAL IMMUNERESPONSES IN THE RESPIRATORY SYSTEM
INDUCTION AND REGULATION OF MUCOSAL ABS INTHE GASTROINTESTINAL SYSTEM
HOMEOSTATIC MAINTENANCE AND BREAKDOWN OFMUCOSAL FIREWALLS
CONCLUDING REMARKS
REFERENCES

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