지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 354 - 363 (10page)
이용수
초록· 키워드
오류제보하기
Eosinophils are multifunctional leukocytes that reside in several tissues, most abundantly in the small intestinal lamina propria under the steady state. To date, the phenotypic and functional characteristics of small intestinal eosinophils have remained poorly understood. In this study, we found that proliferation of ovalbumin (OVA)-specific CD4<SUP>+</SUP> T cells isolated from the mesenteric lymph nodes of eosinophil-deficient ΔdblGATA mice were decreased relative to wild-type mice after oral immunization with OVA and cholera toxin (CT), the typical mucosal adjuvant that induces CD4<SUP>+</SUP> T cell-dependent responses. ΔdblGATA mice showed reduced mucosal secretion of OVA-specific IgA and IgG1 while maintaining a systemic level of anti-OVA IgG1 upon oral immunization with OVA and CT. These findings suggest that eosinophils might have a role in the modulation of T cell-mediated immune responses including mucosal antibody responses in the gastrointestinal tract following oral immunization.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Jung Y / 2014 / Roles and regulation of gastrointestinal eosinophils in immunity and disease / J Immunol 193 : 999 ~ 1005
[학술지(정기간행물)] - Rothenberg ME / 2004 / Eosinophilic gastrointestinal disorders (EGID) / J Allergy Clin Immunol 113 : 11 ~ 28
[학술지(정기간행물)] - Yang D / 2008 / Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses / J Exp Med 205 : 79 ~ 90
[학술지(정기간행물)] - Hirasawa R / 2002 / Essential and instructive roles of GATA factors in eosinophil development / J Exp Med 195 : 1379 ~ 1386
[학술지(정기간행물)] - Jung Y / 2014 / Roles and regulation of gastrointestinal eosinophils in immunity and disease / J Immunol 193 : 999 ~ 1005
[학술지(정기간행물)] - Rothenberg ME / 2004 / Eosinophilic gastrointestinal disorders (EGID) / J Allergy Clin Immunol 113 : 11 ~ 28
[학술지(정기간행물)] - Yang D / 2008 / Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses / J Exp Med 205 : 79 ~ 90
[학술지(정기간행물)] - Hirasawa R / 2002 / Essential and instructive roles of GATA factors in eosinophil development / J Exp Med 195 : 1379 ~ 1386
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Response to “Adult Immunization Policy in Korea”
Infection and Chemotherapy
2024 .03
-
Limitations of immunization registers at community health centers for measuring immunization coverage: a case study of the Japanese encephalitis mass immunization program in Bali Province, Indonesia
Osong Public Health and Research Persptectives
2021 .01
-
CCR3 Monoclonal Antibody Inhibits Eosinophilic Inflammation and Mucosal Injury in a Mouse Model of Eosinophilic Gastroenteritis
Allergy, Asthma & Immunology Research
2017 .01
-
Regulatory Eosinophils in Inflammation and Metabolic Disorders
Immune Network
2017 .02
-
노인의 구강점막 질환
대한치과의사협회지
2020 .11
-
柴胡가 OVA로 유발된 BALB/c mice의 알레르기성 비염 모델에 미치는 영향
동의생리병리학회지
2015 .12
-
柴胡가 OVA로 유발된 BALB/c mice의 알레르기성 비염 모델에 미치는 영향
동의생리병리학회지
2015 .01
-
Investigating immunization via the esophagus: carrageenan’s impact on immune activation
Journal of Biomedical and Translational Research
2024 .06
-
Lipopolysaccharides Facilitate Colonic Motor Alterations Associated to the Sensitization to a Luminal Antigen in Rats
Journal of Neurogastroenterology and Motility (JNM)
2015 .01
-
Recommended immunization schedule for children and adolescents: Committee on Infectious Diseases of the Korean Pediatric Society, 2018
Clinical and Experimental Pediatrics
2019 .01
-
Inhibitory Effects of KM1701 on Airway Cell Infiltration in OVA-Induced Mouse Model
한방안이비인후피부과학회지
2019 .01
-
An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response
Allergy, Asthma & Immunology Research
2020 .01
-
연하장애와 연관된 구강 점막 질환
대한연하장애학회지
2017 .07
-
The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease
Immune Network
2020 .06
-
Effect of Proparacaine in a Mouse Model of Allergic Rhinitis
Clinical and Experimental Otorhinolaryngology
2017 .01
-
Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems
Immune Network
2020 .12
-
Small Intestinal Eosinophils Regulate TH17 Cells By Producing IL-1 Receptor Antagonist
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Revised Adult Immunization Guideline Recommended by the Korean Society of Infectious Diseases, 2014
Infection and Chemotherapy
2015 .01
-
Recent advances in nano/microparticle-based oral vaccines
Journal of Pharmaceutical Investigation
2021 .01
-
세신 전탕액 경구투여가 천식 억제 및 면역조절에 미치는 영향
대한침구의학회지
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-475-002250053