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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 41 - 47 (7page)
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초록· 키워드
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Eosinophils are potent effector cells implicated in allergic responses and helminth infections. Responding to stimuli,
they release their granule-derived cytotoxic proteins and are involved in inflammatory processes. However, under
homeostatic conditions, eosinophils are abundantly present in the intestine and are constantly in contact with the
gut microbiota and maintain the balance of immune responses without inflammation. This situation indicates that
intestinal eosinophils have an anti-inflammatory function unlike allergic eosinophils. In support of this notion,
some papers have shown that eosinophils have different phenotypes depending on the site of residence and are a
heterogeneous cell population. Recently, it was reported that eosinophils in the small intestine and adipose tissue,
respectively, contribute to homeostasis of intestinal immune responses and metabolism. Accordingly, in this review,
we summarize new functions of eosinophils demonstrated in recent studies and discuss their homeostatic functions.
목차
INTRODUCTION
THE ANTI-INFLAMMATORY FUNCTION
ANTIBACTERIAL DEFENSE
METABOLIC HOMEOSTASIS
PROSPECTS
REFERENCES
참고문헌 (40)
참고문헌 신청
Rothenberg, M. E., and S.P. Hogan. 2006. The Eosinophil. Annu. Rev. Immunol. 24: 147-174.
Garcia, N. V., E. Umemoto, Y. Sito, M. Yamasaki, E. Hata, T. Matozaki, M. Murakami, Y.-J. Jung, S.-Y. Woo, J.-Y. Seoh, M. H. Jang, K. Aozasa and M. Miyasaka. 2011. SIRPa/CD172a regulates eosinophil homeostasis. J. Immunol. 187: 2268- 2277.
Carlens, J., B. Wahl, M. Ballmaier, S. Bulfone-Paus, R. Forster and O. Pabst. 2009. Common g-chain-dependent signal confer selevtive survival of eosinophils in the murine small intestine. J. Immunol. 183: 5600-5607.
Mishra, A., S. P. Hogan, J. J. Lee, P. S. Foster, M. E. Rothenberg. 1999. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J. Clin. Invest. 103: 1719- 1727.
Dent, L. A., M. Strath, A. L. Mellor, and C. J. Sanderson. 1990. Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172: 1425-1431.
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UCI(KEPA) : I410-ECN-0101-2017-517-002233599