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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 331 - 337 (7page)
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초록· 키워드
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Synthetic pyrethroids (SPs) are the most common pesticides which are recently used for indoor pest control. The widespread use of SPs has resulted in the increased exposure to wild animals and humans. Recently, some SPs are suspected as endocrine disrupting chemicals (EDCs) and have been assessed for their potential estrogenicity by adopting various analyzing assays. In this study, we examined the estrogenic effects of lambda-cyhalothrin (LC) and cypermethrin (CP), the most commonly used pesticides in Korea, using BG-1 ovarian cancer cells expressing estrogen receptors (ERs). To evaluate the estrogenic activities of two SPs, LC and CP, we employed MTT assay and reverse-transcription polymerase chain reaction (RT-PCR) in LC or CP treated BG-1 ovarian cancer cells. In MTT assay, LC (10<SUP>−6</SUP> M) and CP (10<SUP>−5</SUP> M) significantly induced the growth of BG-1 cancer cells. LC or CP-induced cell growth was antagonized by addition of ICI 182,720 (10<SUP>−8</SUP> M), an ER antagonist, suggesting that this effect appears to be mediated by an ER-dependent manner. Moreover, RT-PCR results showed that transcriptional level of cyclin D1, a cell cycle-regulating gene, was significantly up-regulated by LC and CP, while these effects were reversed by co-treatment of ICI 182,780. However, p21, a cyclin D-ckd-4 inhibitor gene, was not altered by LC or CP. Moreover, ERα expression was not significantly changed by LC and CP, while downregulated by E2. Finally, in xenografted mouse model transplanted with human BG-1 ovarian cancer cells, E2 significantly increased the tumor volume compare to a negative control, but LC did not. Taken together, these results suggest that LC and CP may possess estrogenic potentials by stimulating the growth of BG-1 ovarian cancer cells via partially ER signaling pathway associated with cell cycle as did E2, but this estrogenic effect was not found in in vivo mouse model.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Choi, K.C. / 2003 / The biomarker and endocrine disruptors in mammals / J. Reprod. Dev. 49:337~345
Diamanti-Kandarakis, E. / 2009 / Endocrine-disrupting chemicals: an Endocrine Society scientific statement / Endocr. Rev. 30:293~342
황경아 / 2011 / Gene Alterations of Ovarian Cancer Cells Expressing Estrogen Receptors by Estrogen and Bisphenol A Using Microarray Analysis / Laboratory Animal Research 27(2):99~107
Korach, K. S. / 1991 / Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness / Steroids 56:263~270
Sun, H. / 2007 / Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay / Chemosphere 66:474~479
Diamanti-Kandarakis, E. / 2009 / Endocrine-disrupting chemicals: an Endocrine Society scientific statement / Endocr. Rev. 30:293~342
황경아 / 2011 / Gene Alterations of Ovarian Cancer Cells Expressing Estrogen Receptors by Estrogen and Bisphenol A Using Microarray Analysis / Laboratory Animal Research 27(2):99~107
Korach, K. S. / 1991 / Estrogen receptor stereochemistry: ligand binding and hormonal responsiveness / Steroids 56:263~270
Sun, H. / 2007 / Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay / Chemosphere 66:474~479
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Estrogenic activities of synthetic pyrethroids, lambda-cyhalothrin and cypermethrin, in ovarian cancer cells expressing estrogen receptors via an estrogen receptor-dependent pathway
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UCI(KEPA) : I410-ECN-0101-2016-513-002331421