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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 250 - 263 (14page)
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초록· 키워드
오류제보하기
TM4SF5 is highly expressed in HCC tissues, and causes migration, and invasion. At tetraspanin-enriched microdomain (TEM), the tetraspanins forms protein-protein complexes in hemophilic or heterophilic manner between tetraspanins, integrins, and growth factor receptors. We aimed here to understand the nature of TM4SF5-enriched microdomain with regards to biological significance of the complex among TM4SF5, EGFR and integrin a5 in directional migration, using liver epithelial cells. Their interactions were depending on the N-glycosylation status of TM4SF5, but did not depend on the TM4SF5 palmitoylation. Along the membrane or intracellular cytosolic membrane, colocalization of either two or one of the three could be observed, indicating that TM4SF5 can play roles in directional migration alone or in collaboration with others. TM4SF5 colocalized with EGFR and integrin a5 at the leading edge of migratory cells; the interaction between TM4SF5 and EGFR localized at the leading part of a migratory cell and the interaction between TM4SF5 and integrin a5 spread out the cell more evenly. TM4SF5 at TEM interacts with other molecules appeared to play roles in directing of migration.
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UCI(KEPA) : I410-ECN-0101-2016-519-002373896