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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 437 - 445 (9page)
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Background/Aims: It is important to determine the noninvasive parameters of histological features in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the value of genetic variations as surrogate markers of histological features. Methods: The parameters that affected the histological features of NAFLD were investigated in 211 Japanese patients with biopsy-proven NAFLD. The relationships between genetic variations in PNPLA3 rs738409 or TM6SF2 rs58542926 and histological features were analyzed. Furthermore, the impact of genetic variations that affected the pathological criteria for the diagnosis of nonalcoholic steatohepatitis (NASH) (Matteoni classification and NAFLD activity score) was evaluated. Results: The fibrosis stage of PNPLA3 GG was significantly more progressive than that of CG by multiple comparisons. Multivariate analysis identified PNPLA3 genotypes as predictors of fibrosis of stage 2 or more, but the impact tended to decrease at stage 3 or greater. There were no significant differences among the histological features of the three genotypes of TM6SF2.
PNPLA3 genotypes partly affected the definition of NASH by the NAFLD activity score, but TM6SF2 genotypes did not affect the definition of NASH. Conclusions: In Japanese patients with biopsy-proven NAFLD, PNPLA3 genotypes may partly affect histological features, including stage of fibrosis, but the TM6SF2 genotype does not affect histological features.
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참고문헌 (26)
참고문헌 신청
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346:1221~1231
Williams R / 2006 / Global challenges in liver disease / Hepatology 44:521~526
Torres DM / 2008 / Diagnosis and therapy of nonalcoholic steatohepatitis / Gastroenterology 134:1682~1698
Vuppalanchi R / 2009 / Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management / Hepatology 49:306~317
Kawamura Y / 2012 / Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma / Am J Gastroenterol 107:253~261
Williams R / 2006 / Global challenges in liver disease / Hepatology 44:521~526
Torres DM / 2008 / Diagnosis and therapy of nonalcoholic steatohepatitis / Gastroenterology 134:1682~1698
Vuppalanchi R / 2009 / Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management / Hepatology 49:306~317
Kawamura Y / 2012 / Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma / Am J Gastroenterol 107:253~261
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