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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 537 - 545 (9page)
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This review provides an update on the characteristics of nonalcoholic fatty liver disease (NAFLD), with a focus on the effects of age, sex, and body mass index. Age is a risk factor for NAFLD progression; however, extremely old patients have unique features, namely, the associations between metabolic comorbidities and NAFLD are weaker and NAFLD is not a risk factor for mortality. The prevalence of NAFLD is higher in men than in premenopausal women, whereas the reverse is true after menopause. Thus, before menopause, estrogen may have protective effects against NAFLD. Our hospital data showed that over 25% of male patients with NAFLD and almost 40% of female patients with NAFLD, especially elderly patients, were nonobese. Although histological steatosis and activity were associated with body mass index, the prevalence of nonalcoholic steatohepatitis was not. The prevalence of advanced fibrosis showed a significant sex difference. Advanced fibrosis was significantly more frequent among severely obese men but the prevalence was lower among severely obese women. This difference could be because a substantial proportion of severely obese women were premenopausal; thus, estrogen may have much stronger effects on the development of fibrosis than on obesity. Further studies are required to develop tailored management strategies.
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참고문헌 (66)
참고문헌 신청
Tokushige K / 2016 / Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease : multicenter survey / J Gastroenterol 51:586~596
Yasui K / 2011 / Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma / Clin Gastroenterol Hepatol 9:428~433
Tokushige K / 2015 / Hepatocellular carcinoma based on cryptogenic liver disease : the most common non-viral hepatocellular carcinoma in patients aged over 80 years / Hepatol Res 45:441~447
Taniai M / 2018 / Clinicopathological investigation of steatohepatitic hepatocellular carcinoma : a multicenter study using immunohistochemical analysis of adenomarelated markers / Hepatol Res 48:947~955
Kawada N / 2009 / Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis / J Gastroenterol 44:1190~1194
Yasui K / 2011 / Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma / Clin Gastroenterol Hepatol 9:428~433
Tokushige K / 2015 / Hepatocellular carcinoma based on cryptogenic liver disease : the most common non-viral hepatocellular carcinoma in patients aged over 80 years / Hepatol Res 45:441~447
Taniai M / 2018 / Clinicopathological investigation of steatohepatitic hepatocellular carcinoma : a multicenter study using immunohistochemical analysis of adenomarelated markers / Hepatol Res 48:947~955
Kawada N / 2009 / Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis / J Gastroenterol 44:1190~1194
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