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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제23권 제3호
- 발행연도
- 2020.1
- 수록면
- 276 - 285 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Non-alcoholic fatty liver disease (NAFLD) ranges in severity from simple steatosis to steatohepatitis. Early detection of NAFLD is important for preventing the disease from progressing to become an irreversible end-stage liver disease. We developed a nomogram that allows for non-invasive screening for NAFLD in obese children. Methods: Anthropometric and laboratory data of 180 patients from our pediatric obesity clinic were collected. Diagnoses of NAFLD were based on abdominal ultrasonographic findings. The nomogram was constructed using predictors from a multivariate analysis of NAFLD risk factors. Results: The subjects were divided into non-NAFLD (n=67) and NAFLD groups (n=113). Factors, including sex, body mass index, abdominal circumference, blood pressure, insulin resistance, and levels of aspartate aminotransferase, alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γGT), uric acid, triglycerides, and insulin, were significantly different between the two groups (all p<0.05) as determined using homeostatis model assessment of insulin resistance (HOMA-IR). In our multivariate logistic regression analysis, elevated serum ALT, γGT, and triglyceride levels were significantly related to NAFLD development. The nomogram was established using γGT, uric acid, triglycerides, HOMA-IR, and ALT as predictors of NAFLD probability. Conclusion: The newly developed nomogram may help predict NAFLD risk in obese children. The nomogram may also allow for early NAFLD diagnosis without the need for invasive liver biopsy or expensive liver imaging, and may also allow clinicians to intervene early to prevent the progression of NAFLD to become a more advanced liver disease.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
Wieckowska A / 2005 / Nonalcoholic fatty liver disease in the pediatric population : a review / Curr Opin Pediatr 17:636~641
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease : Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association / Am J Gastroenterol 107:811~826
Feldstein AE / 2009 / The natural history of non-alcoholic fatty liver disease in children : a follow-up study for up to 20 years / Gut 58:1538~1544
Wieckowska A / 2005 / Nonalcoholic fatty liver disease in the pediatric population : a review / Curr Opin Pediatr 17:636~641
Anderson EL / 2015 / The prevalence of non-alcoholic fatty liver disease in children and adolescents : a systematic review and meta-analysis / PLoS One 10:e0140908
Chalasani N / 2012 / The diagnosis and management of non-alcoholic fatty liver disease : Practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association / Am J Gastroenterol 107:811~826
Feldstein AE / 2009 / The natural history of non-alcoholic fatty liver disease in children : a follow-up study for up to 20 years / Gut 58:1538~1544
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