지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 65 - 71 (7page)
이용수
초록· 키워드
오류제보하기
To reduce the expenses for development a novel drug, systems biology has been studied actively. Target prediction, a part of systems biology, contributes to finding a new purpose for FDA(Food and Drug Administration) approved drugs and development novel drugs. In this paper, we propose a classification model for predicting novel target genes based on relation between target genes and disease related genes. After collecting known target genes from TTD(Therapeutic Target Database) and disease related genes from OMIM(Online Mendelian Inheritance in Man), we analyzed the effect of target genes on disease related genes based on PPI(Protein-Protein Interactions) network. We focused on the distinguishing characteristics between known target genes and random target genes, and used the characteristics as features for building a classifier. Because our model is constructed using information about only a disease and its known targets, the model can be applied to unusual diseases without similar drugs and diseases, while existing models for finding new drug-disease associations are based on drug-drug similarity and disease-disease similarity. We validated accuracy of the model using LOOCV of ten times and the AUCs were 0.74 on Alzheimer’s disease and 0.71 on Breast cancer.
목차
Abstract
Ⅰ. Introduction
Ⅱ. Related works
Ⅲ. Method
Ⅳ. Results
Ⅴ. Conclusion
REFERENCES
참고문헌 (24)
참고문헌 신청
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Kitano, Hiroaki. "Computational systems biology." Nature, Vol. 420, No. 6912, pp. 206-210, Nov. 2002.
Landry, Yves, and Jean‐Pierre Gies. "Drugs and their molecular targets: an updated overview." Fundamental & clinical pharmacology, Vol. 22, No. 1, pp. 1-18, Feb. 2008.
Yang, Hong, et al. "Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information." Nucleic acids research, Nov. 2015.
Iorio, Francesco, et al. "Discovery of drug mode of action and drug repositioning from transcriptional responses." Proceedings of the National Academy of Sciences, Vol. 107, No. 33, pp. 14621-14626, Aug. 2010.
Kitano, Hiroaki. "Computational systems biology." Nature, Vol. 420, No. 6912, pp. 206-210, Nov. 2002.
Landry, Yves, and Jean‐Pierre Gies. "Drugs and their molecular targets: an updated overview." Fundamental & clinical pharmacology, Vol. 22, No. 1, pp. 1-18, Feb. 2008.
Yang, Hong, et al. "Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information." Nucleic acids research, Nov. 2015.
Iorio, Francesco, et al. "Discovery of drug mode of action and drug repositioning from transcriptional responses." Proceedings of the National Academy of Sciences, Vol. 107, No. 33, pp. 14621-14626, Aug. 2010.
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UCI(KEPA) : I410-ECN-0101-2016-325-002759952