지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 189 - 194 (6page)
이용수
초록· 키워드
오류제보하기
Obesity is characterized as an accumulation of adipose tissue mass represented by chronic, low-grade inflammation. Obesity-derived inflammation involves chemokines as important regulators contributing to the pathophysiology of obesity-related diseases such as cardiovascular disease, diabetes and some cancers. The obesity-driven chemokine network is poorly understood. Here, we identified the profiles of chemokine signature between human preadipocytes and adipocytes, using PCR arrays and qRT-PCR. Both preadipocytes and adipocytes showed absent or low levels in chemokine receptors in spite of some changes. On the other hand, the chemokine levels of CCL2, CCL7-8, CCL11, CXCL1-3, CXCL6 and CXCL10-11 were dominantly expressed in preadipocytes compared to adipocytes. Interestingly, CXCL14 was the most dominant chemokine expressed in adipocytes compared to preadipocytes. Moreover, there is significantly higher protein level of CXCL14 in conditioned media from adipocytes. In addition, we analyzed the data of the chemokine signatures in adipocytes obtained from healthy lean and obese postmenopausal women based on Gene Expression Omnibus (GEO) dataset. Adipocytes from obese individuals had significantly higher levels in chemokine signature as follows: CCL2, CCL13, CCL18-19, CCL23, CCL26, CXCL1, CXCL3 and CXCL14, as compared to those from lean ones. Also, among the chemokine networks, CXCL14 appeared to be the highest levels in adipocytes from both lean and obese women. Taken together, these results identify CXCL14 as an important chemokine induced during adipogenesis, requiring further research elucidating its potential therapeutic benefits in obesity.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Wagner, M / 2015 / Adipose tissue macrophages: the inflammatory link between obesity and cancer? / Expert Opin. Ther. Targets 19 : 527 ~ 538
[학술지(정기간행물)] - Lafontan, M / 2014 / Adipose tissue and adipocyte dysregulation / Diabetes Metab 40 : 16 ~ 28
[학술지(정기간행물)] - Crunkhorn, S / 2013 / Metabolic disorders: Breaking the links between inflammation and diabetes / Nat. Rev. Drug Discov 12 : 261 ~
[학술지(정기간행물)] - Calle, E. E / 2004 / Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms / Nat. Rev. Cancer 4 : 579 ~ 591
[학술지(정기간행물)] - Hotamisligil, G. S / 2006 / Inflammation and metabolic disorders / Nature 444 : 860 ~ 867
[학술지(정기간행물)] - Lafontan, M / 2014 / Adipose tissue and adipocyte dysregulation / Diabetes Metab 40 : 16 ~ 28
[학술지(정기간행물)] - Crunkhorn, S / 2013 / Metabolic disorders: Breaking the links between inflammation and diabetes / Nat. Rev. Drug Discov 12 : 261 ~
[학술지(정기간행물)] - Calle, E. E / 2004 / Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms / Nat. Rev. Cancer 4 : 579 ~ 591
[학술지(정기간행물)] - Hotamisligil, G. S / 2006 / Inflammation and metabolic disorders / Nature 444 : 860 ~ 867
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study
Cancer Research and Treatment
2015 .01
-
Gene Expression Profiles of Th1-type Chemokines in Whole Blood of Mycobacterium avium subsp. paratuberculosis-Infected Cattle
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .12
-
Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites
Immune Network
2018 .12
-
Chemokine (C-X-C Motif) Ligand 1 (CXCL1) Expression in the Minor Salivary Glands of Sjögren’s Syndrome Patients
대한류마티스학회지
2016 .01
-
Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
Immune Network
2018 .08
-
Chemokine Expression during Adipogenesis and Inflammation in Orbital Fibroblasts from Patients with Graves' Orbitopathy
Korean Journal of Ophthalmology
2020 .01
-
The effect of CXCL5/CXCL8 on neutrophilic inflammation in peri-implantitis
한국실험동물학회 학술발표대회 논문집
2025 .02
-
The Roles of Chemokines in Immune Response to Mycobacterial Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .12
-
Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24
Journal of Pathology and Translational Medicine
2016 .01
-
CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer
Cancer Research and Treatment
2020 .01
-
Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis
Yonsei Medical Journal
2015 .01
-
Comparison of CXCL10 Secretion in Colorectal Cancer Cell Lines
대한의생명과학회지
2022 .09
-
Association of Chemokines and Chemokine Receptor Expression with Monocytic-Myeloid-Derived Suppressor Cells during Tumor Progression
Immune Network
2018 .06
-
Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes
Annals of Dermatology
2015 .01
-
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults
Endocrinology and Metabolism
2021 .01
-
Serum CCL11 Levels in Benign Prostatic Hyperplasia and Prostate Cancer
Urogenital Tract Infection
2016 .01
-
Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder
PSYCHIATRY INVESTIGATION
2016 .01
-
Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer
Immune Network
2019 .06
-
Expression of Chemokine CCL28 in Ulcerative Colitis Patients
Gut and Liver
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-517-000870518