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논문 기본 정보

자료유형
학술저널
저자정보
Lee Dong Seok (Departments of Gastroenterology SMG-SNU Boramae Medical Center Seoul National University of College) Lee Kook Lae (Departments of Gastroenterology SMG-SNU Boramae Medical Center Seoul National University of College) Jeong Ji Bong (Departments of Gastroenterology SMG-SNU Boramae Medical Center Seoul National University of College) Shin Sue (Departments of Laboratory Medicine SMG-SNU Boramae Medical Center Seoul National University of Coll) Kim Su Hwan (Departments of Gastroenterology SMG-SNU Boramae Medical Center Seoul National University of College) Kim Ji Won (Departments of Gastroenterology SMG-SNU Boramae Medical Center Seoul National University of College)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제1호
발행연도
2021.1
수록면
70 - 76 (7page)

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Background/Aims: Ulcerative colitis (UC) is an inflammatory bowel disease for which new serological markers are required. The purpose of this study was to assess the role of the mucosaassociated epithelial chemokine CCL28 in UC. Methods: The study included 50 patients; of these, 25 were patients with UC, and 25 were healthy controls. The levels of serum CCL28 were analyzed using enzyme-linked immunosorbent assay. CCL28 expression was analyzed by immunohistochemistry (IHC) in 15 representative colon tissues biopsied based on disease activity (UC patients with severe activity, five samples; UC patients with mild activity, five samples; healthy controls, five samples). Results: The serum CCL28 levels were remarkably higher (p<0.05) in patients with UC (median, 235.7 pg/mL; IQR, 63.8 to 117.2 pg/mL) than in healthy controls (median, 48.9, pg/mL; IQR, 35.9 to 42.0 pg/mL). However, there was no significant difference in serum CCL28 according to disease extent or activity. In contrast, IHC analysis revealed a significant difference in CCL28 consistent with disease status, disease extent, and disease activity. Conclusions: CCL28 could be useful for diagnosing UC. However, further validations of CCL28 on disease activity and severity are needed.

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