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Background: Liver failure is usually associated with the inflammation and oxidation of hepatocytes. Due to their unique properties, graphene and graphene-based nanostructures such as magnetic graphene oxide (MGO) are useful in biomedicine and engineering. In this study, synthesized MGO was used to improve the liver failure induced by carbon tetrachloride (CCl4). The hepatoprotective effects of intraperitoneal injection of MGO on the rat model of CCl4-induced acute liver failure were investigated. Materials and methods: In order to provide a rat model of acute liver failure, male rats were intraperitoneally injected with 2 ml/kg body weight CCl4. In the experimental groups, rats received 2 ml/kg CCl4 and 300 mg/kg MGO body weight simultaneously. Four days after injection, symptoms of acute liver failure appeared. The control, sham, CCl4, and CCl4 + MGO groups were compared and analyzed both histologically and biochemically. Results: The results indicated that the MGO injection reduced all CCl4-induced liver failure such as necrosis, fibrosis, inflammation, aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in the experimental groups of the rat model of acute liver failure. Conclusion: The hepatoprotective effects of MGO might be due to histopathological suppression and inflammation inhibition in the liver.
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참고문헌 (51)
참고문헌 신청
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Benyon RC / 2001 / Extracellular matrix degradation and the role of hepatic stellate cells / Semin Liver Dis 21:373~384
Manuelpillai U / 2010 / Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl4-treated mice / Cell Transplant 19:1157~1168
Hayashi S / 2008 / Fucoidan partly prevents CCl4-induced liver fibrosis / Eur J Pharmacol 580:380~384
Greenwel P / 2000 / Hydrogen peroxide : a link between acetaldehyde-elicited alpha1(I)collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells / Hepatology 31:109~116
Benyon RC / 2001 / Extracellular matrix degradation and the role of hepatic stellate cells / Semin Liver Dis 21:373~384
Manuelpillai U / 2010 / Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl4-treated mice / Cell Transplant 19:1157~1168
Hayashi S / 2008 / Fucoidan partly prevents CCl4-induced liver fibrosis / Eur J Pharmacol 580:380~384
Greenwel P / 2000 / Hydrogen peroxide : a link between acetaldehyde-elicited alpha1(I)collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells / Hepatology 31:109~116
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