지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
High risk human papillomavirus (HR-HPV) is major risk factor for uterine cervical cancer. There are approximately 15 types of HR-HPV. Liquid based cytology samples (116 samples) with high grade cervical lesions belonging to cervical intraepithelial neoplasia (CIN) 2, CIN 3, carcinoma in situ (CIS) and squamous cell carcinoma (SCC) were used after histologic confirmation. HR-HPV genotype assay was conducted using DNA chips. The HR-HPV infection rate was 81.9% with SCC samples showing the highest HR-HPV infection rate of 31%. CIN 3, CIS and CIN 2 showed infection rates of 25%, 16.4% and 9.5%, respectively. According to age with HR HPV infection rate, the 30~39 years-old group showed the highest infection rate by 92.3%. According to distribution with HR HPV genotyping, HPV 16 showed the highest infection rate by 42.3% whereas HPV 33 and HPV 58 showed infection rates of 11.7% and 10.8%, respectively. HPV 18 which is the second most common infected HPV genotype in the world showed 3.6%. Of the three most common oncogenic HR-HPV genotypes in CIN 2, we detected HPV 16, 35, 58; CIN 3 was HPV 16, 33, 58; CIS was HPV 16, 58, 33 (35/52); and SCC was HPV 16, 33, and 18 (31/52/58). Among the HPV 18, CIN 2, CIN 3, CIS and SCC showed 0.9%, 0.9%, 0% and 1.8%, respectively. The most often used preventive vaccines for cervical cancers use HPV 16 and HPV 18 as targets. However, results derived from this study suggest that a preventive vaccine against HPV 16 and HPV 18 would not be optimal for populations in this study.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
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[학술지(정기간행물)] - Bao YP / 2008 / Human papillomavirus type distribution in women from Asia: a meta-analysis / Int J Gynecol Cancer 18 : 71 ~ 79
[학술지(정기간행물)] - Bosch FX / 1995 / Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group / J Natl Cancer Inst 87 : 796 ~ 802
[학술지(정기간행물)] - Bouvard V / 2009 / A review of human carcinogens―part B: biological agents / Lancet Oncol 10 : 321 ~ 322
[학술지(정기간행물)] - Bruni L / 2010 / Cervical human papillomavirus prevalence in 5 continents:meta-analysis of 1 million women with normal cytological findings / J Infect Dis 202 : 1789 ~ 1799
[학술지(정기간행물)] - Bao YP / 2008 / Human papillomavirus type distribution in women from Asia: a meta-analysis / Int J Gynecol Cancer 18 : 71 ~ 79
[학술지(정기간행물)] - Bosch FX / 1995 / Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group / J Natl Cancer Inst 87 : 796 ~ 802
[학술지(정기간행물)] - Bouvard V / 2009 / A review of human carcinogens―part B: biological agents / Lancet Oncol 10 : 321 ~ 322
[학술지(정기간행물)] - Bruni L / 2010 / Cervical human papillomavirus prevalence in 5 continents:meta-analysis of 1 million women with normal cytological findings / J Infect Dis 202 : 1789 ~ 1799
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E2/E6 ratio and L1 immunoreactivity as biomarkers to determine HPV16-positive high-grade squamous intraepithelial lesions (CIN2 and 3) and cervical squamous cell carcinoma
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Evaluation of the characteristics of multiple human papillomavirus (HPV) infections identified using the BD Onclarity HPV assay and comparison with those of single HPV infection
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Evaluation of partial genotyping with HPV16/18 for triage of HPV positive, cytology negative women in the COMPACT study
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Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review
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Human Papillomavirus Genotyping and p16INK4a Expression in Cervical Lesions: A Combined Test to Avoid Cervical Cancer Progression
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Overview of the Efficacy of Human Papillomavirus Virus Vaccines
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Analysis of HR-HPV Prevalence among Unvaccinated Busan Women
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Multifaceted Usage of HPV Related Tests and Products in the Management of Cervical Cancer - a Review
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UCI(KEPA) : I410-ECN-0101-2017-510-000852071